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- W1964548954 abstract "Abstract The in vitro metabolism of EPN (O-ethyl O-p-nitrophenyl phenylphosphonothionate) and EPNO (O-ethyl O-p-nitrophenyl phenylphosphonate) in mouse liver was studied. EPNO was metabolized faster than EPN, and the highest metabolic activity was found in the 10,000g supernatant in the presence of both NADPH and glutathione. Liver microsomes in the presence of NADPH metabolize EPN to its oxygen analog, EPNO and p-nitrophenol. With the 100,000g supernatant only slight metabolism of EPN occurred in the presence of GSH. Metabolism of EPNO by liver microsomes increased upon the addition of NADPH. p-Nitrophenol was the only metabolite isolated in the presence of microsomes, whereas, with the addition of NADPH, both p-nitrophenol and desethyl EPNO were formed. Quantitative studies showed that there was little, if any, oxidative dearylation of EPNO by liver microsomes. The 100,000g supernatant was found to actively degrade EPNO, and this increased upon addition of glutathione. The initial rate of p-nitrophenol formation as a result of incubation of EPN and EPNO with liver microsomes was found to be higher with EPN than EPNO." @default.
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- W1964548954 date "1979-04-01" @default.
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- W1964548954 title "In vitro metabolism of EPN and EPNO by mouse liver" @default.
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- W1964548954 doi "https://doi.org/10.1016/0048-3575(79)90021-x" @default.
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