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• W1964549183 abstract "The vav proto-oncogene product (Vav) is expressed exclusively in hematopoietic cells and is reported to have guanine nucleotide exchange activity. Here we report that granulocyte-macrophage colony-stimulating factor, interleukin-3, and erythropoietin induce tyrosine phosphorylation of Vav in a human leukemia cell line UT-7. Tyrosine phosphorylation of Vav is rapid and transient; it occurs within 1 min of the stimulation and at physiological concentrations of the factors. Furthermore, we show that Vav is constitutively associated with the adapter molecule Grb2/Ash in UT-7. These data suggest that tyrosine kinases, the adapter Grb2/Ash, and the guanine nucleotide exchange factor Vav are members of a signaling pathway leading to Ras activation in hematopoietic cells." @default.
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• W1964549183 date "1995-04-01" @default.
• W1964549183 modified "2023-10-03" @default.
• W1964549183 title "Tyrosine Phosphorylation of the Proto-oncogene Product Vav and Its Association with the Adapter Grb2/Ash in a Human Leukemia Cell Line UT-7" @default.
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• W1964549183 doi "https://doi.org/10.1111/j.1349-7006.1995.tb03061.x" @default.
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