FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964551392> ?p ?o ?g. }

• W1964551392 endingPage "15163" @default.
• W1964551392 startingPage "15155" @default.
• W1964551392 abstract "The sequential addition of water molecules to protonated and deprotonated forms of the four mononucleotides dAMP, dCMP, dGMP, and dTMP was studied experimentally by equilibrium measurements using an electrospray mass spectrometer equipped with a drift cell and theoretically by computational methods including molecular modeling and density functional theory calculations. Experiments were carried out in positive and negative ion mode, and calculations included the protonated and deprotonated forms of the four nucleotides. For deprotonated anionic nucleotides the experimental enthalpies of hydration (DeltaH degrees n) were found to be similar for all four systems and varied between -10.1 and -11.5 kcal mol-1 for the first water molecule (n = 1) and -8.3 and -9.6 kcal mol-1 for additional water molecules (n = 2-4). Theory indicated that the first water molecule binds to the charge-carrying phosphate group. Simulations of deprotonated mononucleotides with four water molecules yielded a large number of structures with similar energies. In some of the structures all four water molecules cluster around the phosphate group, and in other structures the four water molecules each hydrate a different functional group of the nucleotide. These include the phosphate group, the deoxyribose hydroxyl group, and various functional groups on the nucleobases. Experimental DeltaH degrees 1 values for the protonated cationic mononucleotides ranged from -10.5 to -13.5 kcal mol-1 with more negative values (< or =-12 kcal mol-1) for dCMP, dGMP, and dTMP and the least negative value for dAMP. For n = 2-4 DeltaH degrees n values varied from -6.9 to -9.7 kcal/mol and were similar in value to the deprotonated nucleotides except for dAMP. Theory on the protonated nucleotides indicated that the first water molecule binds to the charge-carrying group for dCMP, dGMP, and dTMP. For protonated dAMP, on the other hand, the charge-carrying N3 group is well self-solvated by the phosphate group and not readily available for a hydrogen bond with the water molecule. The insight gained on nucleotide stabilization by individual water molecules is used to discuss the competition between hydration of individual nucleotides and Watson-Crick base pairing." @default.
• W1964551392 created "2016-06-24" @default.
• W1964551392 creator A5008184092 @default.
• W1964551392 creator A5033847316 @default.
• W1964551392 creator A5034571226 @default.
• W1964551392 date "2006-11-01" @default.
• W1964551392 modified "2023-09-29" @default.
• W1964551392 title "Hydration of Mononucleotides" @default.
• W1964551392 cites W1518002808 @default.
• W1964551392 cites W1577332561 @default.
• W1964551392 cites W1965911672 @default.
• W1964551392 cites W1971353786 @default.
• W1964551392 cites W1976477262 @default.
• W1964551392 cites W1980803935 @default.
• W1964551392 cites W1987625718 @default.
• W1964551392 cites W1992043136 @default.
• W1964551392 cites W2002864684 @default.
• W1964551392 cites W2007002591 @default.
• W1964551392 cites W2012673821 @default.
• W1964551392 cites W2013739357 @default.
• W1964551392 cites W2020282973 @default.
• W1964551392 cites W2023271753 @default.
• W1964551392 cites W2026251720 @default.
• W1964551392 cites W2028726006 @default.
• W1964551392 cites W2030168725 @default.
• W1964551392 cites W2031668095 @default.
• W1964551392 cites W2038935614 @default.
• W1964551392 cites W2040882599 @default.
• W1964551392 cites W2059671641 @default.
• W1964551392 cites W2061108943 @default.
• W1964551392 cites W2061395895 @default.
• W1964551392 cites W2062191252 @default.
• W1964551392 cites W2065447685 @default.
• W1964551392 cites W2078420278 @default.
• W1964551392 cites W2083009384 @default.
• W1964551392 cites W2083022414 @default.
• W1964551392 cites W2083891900 @default.
• W1964551392 cites W2085965241 @default.
• W1964551392 cites W2090434591 @default.
• W1964551392 cites W2091483905 @default.
• W1964551392 cites W2097854161 @default.
• W1964551392 cites W2104042038 @default.
• W1964551392 cites W2126466006 @default.
• W1964551392 cites W2143981217 @default.
• W1964551392 cites W2148941593 @default.
• W1964551392 cites W2330089154 @default.
• W1964551392 cites W2949518225 @default.
• W1964551392 cites W319836565 @default.
• W1964551392 cites W2144920038 @default.
• W1964551392 doi "https://doi.org/10.1021/ja062418o" @default.
• W1964551392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17117867" @default.
• W1964551392 hasPublicationYear "2006" @default.
• W1964551392 type Work @default.
• W1964551392 sameAs 1964551392 @default.
• W1964551392 citedByCount "53" @default.
• W1964551392 countsByYear W19645513922012 @default.
• W1964551392 countsByYear W19645513922013 @default.
• W1964551392 countsByYear W19645513922014 @default.
• W1964551392 countsByYear W19645513922015 @default.
• W1964551392 countsByYear W19645513922016 @default.
• W1964551392 countsByYear W19645513922017 @default.
• W1964551392 countsByYear W19645513922019 @default.
• W1964551392 countsByYear W19645513922020 @default.
• W1964551392 countsByYear W19645513922021 @default.
• W1964551392 countsByYear W19645513922022 @default.
• W1964551392 crossrefType "journal-article" @default.
• W1964551392 hasAuthorship W1964551392A5008184092 @default.
• W1964551392 hasAuthorship W1964551392A5033847316 @default.
• W1964551392 hasAuthorship W1964551392A5034571226 @default.
• W1964551392 hasConcept C104317684 @default.
• W1964551392 hasConcept C118629725 @default.
• W1964551392 hasConcept C145148216 @default.
• W1964551392 hasConcept C147597530 @default.
• W1964551392 hasConcept C152365726 @default.
• W1964551392 hasConcept C178790620 @default.
• W1964551392 hasConcept C185592680 @default.
• W1964551392 hasConcept C2777132085 @default.
• W1964551392 hasConcept C30095370 @default.
• W1964551392 hasConcept C32909587 @default.
• W1964551392 hasConcept C512185932 @default.
• W1964551392 hasConcept C552990157 @default.
• W1964551392 hasConcept C55493867 @default.
• W1964551392 hasConcept C61234307 @default.
• W1964551392 hasConcept C71240020 @default.
• W1964551392 hasConcept C8010536 @default.
• W1964551392 hasConceptScore W1964551392C104317684 @default.
• W1964551392 hasConceptScore W1964551392C118629725 @default.
• W1964551392 hasConceptScore W1964551392C145148216 @default.
• W1964551392 hasConceptScore W1964551392C147597530 @default.
• W1964551392 hasConceptScore W1964551392C152365726 @default.
• W1964551392 hasConceptScore W1964551392C178790620 @default.
• W1964551392 hasConceptScore W1964551392C185592680 @default.
• W1964551392 hasConceptScore W1964551392C2777132085 @default.
• W1964551392 hasConceptScore W1964551392C30095370 @default.
• W1964551392 hasConceptScore W1964551392C32909587 @default.
• W1964551392 hasConceptScore W1964551392C512185932 @default.
• W1964551392 hasConceptScore W1964551392C552990157 @default.
• W1964551392 hasConceptScore W1964551392C55493867 @default.

• next