Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964553903> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1964553903 endingPage "87" @default.
- W1964553903 startingPage "82" @default.
- W1964553903 abstract "Influenza virus attaches primarily to ciliated cells in mature airways epithelium. This process is mediated by a viral envelope glycoprotein (hemagglutinin) that binds to sialic acid-containing receptors in the apical membrane of host cells. The purpose of this study was to determine the cellular distribution of these receptors as a function of tracheal epithelial maturation in the ferret, which is susceptible to influenza virus infection at all ages and undergoes postnatal ciliation. To assay for virus attachment, tracheal strips from ferrets at ages 0, 7, 14, and 28 d were incubated at 4°C for 1 h with a concentrated suspension of influenza A virus. Transmission electron microscopy demonstrated virus attachment to the apical surface of 77 to 87% of ciliated cells, but only to 1 to 9% of nonciliated surface epithelial cells at all ages, including the newborn, which has few ciliated cells (< 10% of total cells). Virions also attached to most of the preciliated cells identified. Pretreatment of tracheal strips with neuraminidase virtually eliminated viral attachment. These findings demonstrate preferential influenza virus binding to sialylated receptors on ciliated cells and their immediate precursors. The sparsity of ciliated cells with no evidence for increased influenza virus binding per cell in newborn ferret tracheas suggests that the previously demonstrated high risk of death from influenza infection in newborn ferrets is due to factors other than increased susceptibility to virus attachment. Influenza virus receptors appear to be selective membrane markers for ciliated cells and may be particularly useful for the identification of preciliated cells." @default.
- W1964553903 created "2016-06-24" @default.
- W1964553903 creator A5004906447 @default.
- W1964553903 creator A5008252959 @default.
- W1964553903 creator A5020287806 @default.
- W1964553903 creator A5052633687 @default.
- W1964553903 date "1991-01-01" @default.
- W1964553903 modified "2023-09-25" @default.
- W1964553903 title "Attachment of Influenza A Virus to Ferret Tracheal Epithelium at Different Maturational Stages" @default.
- W1964553903 cites W1819589015 @default.
- W1964553903 cites W1970970379 @default.
- W1964553903 cites W1990184373 @default.
- W1964553903 cites W2001066584 @default.
- W1964553903 cites W2005130550 @default.
- W1964553903 cites W2009296046 @default.
- W1964553903 cites W2043082402 @default.
- W1964553903 cites W2055518352 @default.
- W1964553903 cites W2075610059 @default.
- W1964553903 cites W2082030984 @default.
- W1964553903 cites W2123150998 @default.
- W1964553903 cites W2140159565 @default.
- W1964553903 cites W2142671293 @default.
- W1964553903 cites W2154116964 @default.
- W1964553903 cites W2012737751 @default.
- W1964553903 doi "https://doi.org/10.1165/ajrcmb/4.1.82" @default.
- W1964553903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1986780" @default.
- W1964553903 hasPublicationYear "1991" @default.
- W1964553903 type Work @default.
- W1964553903 sameAs 1964553903 @default.
- W1964553903 citedByCount "20" @default.
- W1964553903 countsByYear W19645539032012 @default.
- W1964553903 countsByYear W19645539032013 @default.
- W1964553903 crossrefType "journal-article" @default.
- W1964553903 hasAuthorship W1964553903A5004906447 @default.
- W1964553903 hasAuthorship W1964553903A5008252959 @default.
- W1964553903 hasAuthorship W1964553903A5020287806 @default.
- W1964553903 hasAuthorship W1964553903A5052633687 @default.
- W1964553903 hasConcept C108625454 @default.
- W1964553903 hasConcept C134164806 @default.
- W1964553903 hasConcept C140704245 @default.
- W1964553903 hasConcept C153911025 @default.
- W1964553903 hasConcept C159047783 @default.
- W1964553903 hasConcept C170493617 @default.
- W1964553903 hasConcept C2522874641 @default.
- W1964553903 hasConcept C2777546802 @default.
- W1964553903 hasConcept C2778692840 @default.
- W1964553903 hasConcept C2780115458 @default.
- W1964553903 hasConcept C2781416681 @default.
- W1964553903 hasConcept C3018436504 @default.
- W1964553903 hasConcept C529295009 @default.
- W1964553903 hasConcept C54355233 @default.
- W1964553903 hasConcept C55493867 @default.
- W1964553903 hasConcept C58475186 @default.
- W1964553903 hasConcept C86803240 @default.
- W1964553903 hasConcept C97380033 @default.
- W1964553903 hasConceptScore W1964553903C108625454 @default.
- W1964553903 hasConceptScore W1964553903C134164806 @default.
- W1964553903 hasConceptScore W1964553903C140704245 @default.
- W1964553903 hasConceptScore W1964553903C153911025 @default.
- W1964553903 hasConceptScore W1964553903C159047783 @default.
- W1964553903 hasConceptScore W1964553903C170493617 @default.
- W1964553903 hasConceptScore W1964553903C2522874641 @default.
- W1964553903 hasConceptScore W1964553903C2777546802 @default.
- W1964553903 hasConceptScore W1964553903C2778692840 @default.
- W1964553903 hasConceptScore W1964553903C2780115458 @default.
- W1964553903 hasConceptScore W1964553903C2781416681 @default.
- W1964553903 hasConceptScore W1964553903C3018436504 @default.
- W1964553903 hasConceptScore W1964553903C529295009 @default.
- W1964553903 hasConceptScore W1964553903C54355233 @default.
- W1964553903 hasConceptScore W1964553903C55493867 @default.
- W1964553903 hasConceptScore W1964553903C58475186 @default.
- W1964553903 hasConceptScore W1964553903C86803240 @default.
- W1964553903 hasConceptScore W1964553903C97380033 @default.
- W1964553903 hasIssue "1" @default.
- W1964553903 hasLocation W19645539031 @default.
- W1964553903 hasLocation W19645539032 @default.
- W1964553903 hasOpenAccess W1964553903 @default.
- W1964553903 hasPrimaryLocation W19645539031 @default.
- W1964553903 hasRelatedWork W127310600 @default.
- W1964553903 hasRelatedWork W1964553903 @default.
- W1964553903 hasRelatedWork W1970078779 @default.
- W1964553903 hasRelatedWork W2069366769 @default.
- W1964553903 hasRelatedWork W2076734315 @default.
- W1964553903 hasRelatedWork W2140188877 @default.
- W1964553903 hasRelatedWork W2314154639 @default.
- W1964553903 hasRelatedWork W2482073373 @default.
- W1964553903 hasRelatedWork W2945108500 @default.
- W1964553903 hasRelatedWork W3021547748 @default.
- W1964553903 hasVolume "4" @default.
- W1964553903 isParatext "false" @default.
- W1964553903 isRetracted "false" @default.
- W1964553903 magId "1964553903" @default.
- W1964553903 workType "article" @default.