Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964558045> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W1964558045 endingPage "154" @default.
- W1964558045 startingPage "154" @default.
- W1964558045 abstract "Previous studies showed that the 5-HT2 receptor antagonist, amperozide, is somewhat more potent than the opiate antagonist, naltrexone, in reducing alcohol drinking in high alcohol-preferring (P) rats. The purpose of this study was to determine in the P rat whether the effect of either drug could be due, in part, to an alteration in gustatory function. In an unlimited, 24-h free choice paradigm, P rats were offered water simultaneously with either a highly palatable 0.1% saccharin solution or a 1:4 dilution of Nestlé Sweet Success chocolate drink. Throughout all phases of the study, the P rats always consumed significantly greater volumes of the chocolate drink than of the saccharin solution, i.e., 526 ml/kg vs. 181 ml/kg, respectively. Successive 12-day experimental periods consisted of three phases: a 4-day predrug control interval; 4 days of administration of saline control vehicle or either drug; and a final 4 day postdrug interval. In a counterbalance design, saline, amperozide (1.0 or 5.0 mg/kg) or naltrexone (2.5 or 5.0 mg/kg) was administered subcutaneously twice daily at 1600 and 2200 h for 4 days. Amperozide and naltrexone significantly reduced the drinking of chocolate in a dose-dependent manner. Conversely, only the two higher doses of amperozide and naltrexone decreased the intake of saccharin significantly. Thus, these findings suggest that different populations of central serotonin and opioid receptors concurrently underpin, in part, the preferences for both palatable and/or nutrient fluids. Finally, because both the opiate and 5-HT2A antagonists reduce the ingestion of saccharin and chocolate solutions differentially, it is apparent that preferences for alternative palatable fluids should be examined when candidate drugs are screened for suppressing alcohol drinking and ultimately the treatment of alcohol abuse." @default.
- W1964558045 created "2016-06-24" @default.
- W1964558045 creator A5002385330 @default.
- W1964558045 creator A5069013958 @default.
- W1964558045 creator A5073850836 @default.
- W1964558045 creator A5077571103 @default.
- W1964558045 creator A5085292438 @default.
- W1964558045 date "1993-04-01" @default.
- W1964558045 modified "2023-09-27" @default.
- W1964558045 title "Auditory event related potentials in chronic schizophrenia" @default.
- W1964558045 doi "https://doi.org/10.1016/0920-9964(93)90277-p" @default.
- W1964558045 hasPublicationYear "1993" @default.
- W1964558045 type Work @default.
- W1964558045 sameAs 1964558045 @default.
- W1964558045 citedByCount "0" @default.
- W1964558045 crossrefType "journal-article" @default.
- W1964558045 hasAuthorship W1964558045A5002385330 @default.
- W1964558045 hasAuthorship W1964558045A5069013958 @default.
- W1964558045 hasAuthorship W1964558045A5073850836 @default.
- W1964558045 hasAuthorship W1964558045A5077571103 @default.
- W1964558045 hasAuthorship W1964558045A5085292438 @default.
- W1964558045 hasConcept C134018914 @default.
- W1964558045 hasConcept C170493617 @default.
- W1964558045 hasConcept C185592680 @default.
- W1964558045 hasConcept C2776885963 @default.
- W1964558045 hasConcept C2777397205 @default.
- W1964558045 hasConcept C2777972943 @default.
- W1964558045 hasConcept C2778122271 @default.
- W1964558045 hasConcept C2778140631 @default.
- W1964558045 hasConcept C2779147919 @default.
- W1964558045 hasConcept C2781063702 @default.
- W1964558045 hasConcept C42219234 @default.
- W1964558045 hasConcept C55493867 @default.
- W1964558045 hasConcept C71924100 @default.
- W1964558045 hasConcept C98274493 @default.
- W1964558045 hasConceptScore W1964558045C134018914 @default.
- W1964558045 hasConceptScore W1964558045C170493617 @default.
- W1964558045 hasConceptScore W1964558045C185592680 @default.
- W1964558045 hasConceptScore W1964558045C2776885963 @default.
- W1964558045 hasConceptScore W1964558045C2777397205 @default.
- W1964558045 hasConceptScore W1964558045C2777972943 @default.
- W1964558045 hasConceptScore W1964558045C2778122271 @default.
- W1964558045 hasConceptScore W1964558045C2778140631 @default.
- W1964558045 hasConceptScore W1964558045C2779147919 @default.
- W1964558045 hasConceptScore W1964558045C2781063702 @default.
- W1964558045 hasConceptScore W1964558045C42219234 @default.
- W1964558045 hasConceptScore W1964558045C55493867 @default.
- W1964558045 hasConceptScore W1964558045C71924100 @default.
- W1964558045 hasConceptScore W1964558045C98274493 @default.
- W1964558045 hasIssue "2-3" @default.
- W1964558045 hasLocation W19645580451 @default.
- W1964558045 hasOpenAccess W1964558045 @default.
- W1964558045 hasPrimaryLocation W19645580451 @default.
- W1964558045 hasRelatedWork W1533997892 @default.
- W1964558045 hasRelatedWork W1577133669 @default.
- W1964558045 hasRelatedWork W1596813552 @default.
- W1964558045 hasRelatedWork W1979335616 @default.
- W1964558045 hasRelatedWork W2019317841 @default.
- W1964558045 hasRelatedWork W2056316639 @default.
- W1964558045 hasRelatedWork W2061493991 @default.
- W1964558045 hasRelatedWork W2089497531 @default.
- W1964558045 hasRelatedWork W2097635080 @default.
- W1964558045 hasRelatedWork W4319600105 @default.
- W1964558045 hasVolume "9" @default.
- W1964558045 isParatext "false" @default.
- W1964558045 isRetracted "false" @default.
- W1964558045 magId "1964558045" @default.
- W1964558045 workType "article" @default.