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- W1964559136 abstract "Influx of calcium through membrane channels is an important initial step in signal transduction of growth signals. Therefore, the effects of Ras protein injection on calcium currents across the soma membrane of an identified neuron of the snail Hermissenda were examined. With the use of these post-mitotic cells, a voltage-sensitive, inward calcium current was increased 10 to 20 minutes after Harvey-ras oncoproteins were injected. The effects of oncogenic Harvey ras p21 protein (v-Ras) occurred quickly and were sustained, whereas the effects of proto-oncogenic ras protein (c-Ras) were transient. This relative potency is consistent with the activities of these oncoproteins in stimulating cell proliferation. Thus, this calcium channel may be a target for Ras action." @default.
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- W1964559136 date "1990-12-21" @default.
- W1964559136 modified "2023-10-14" @default.
- W1964559136 title "Early Enhancement of Calcium Currents by H- <i>ras</i> Oncoproteins Injected into <i>Hermissenda</i> Neurons" @default.
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- W1964559136 doi "https://doi.org/10.1126/science.2176747" @default.
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