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- W1964562166 abstract "Cystic fibrosis (CF) is characterized by chronic infection and inflammation in the airways that lead to progressive lung damage and early death. Current anti-inflammatory therapies are limited by extensive adverse effects or insufficient efficacy. There is a large body of studies indicating beneficial anti-microbial and anti-inflammatory properties of vitamin D. Since most patients with CF present with vitamin D deficiency, and serum vitamin D levels demonstrate a positive correlation with lung function and negative correlation with airway inflammation and infection, correcting vitamin D deficiency may be an attractive therapeutic strategy in CF. The function of vitamin D is intricately tied to its metabolism, which may be impaired at multiple steps in patients with CF, with a potential to limit the efficacy of vitamin D supplementation. It is likely that the aforementioned beneficial properties of vitamin D require supplementation with doses of vitamin D markedly higher than those recommended to maintain proper bone function. This review will illustrate the potential for supplementation with vitamin D or its metabolites to modulate inflammation and improve defence against chronic infection in CF lung, as well as appropriate vitamin D supplementation strategies for improving lung function in CF." @default.
- W1964562166 created "2016-06-24" @default.
- W1964562166 creator A5021901164 @default.
- W1964562166 creator A5053473599 @default.
- W1964562166 creator A5073861452 @default.
- W1964562166 date "2014-06-01" @default.
- W1964562166 modified "2023-09-27" @default.
- W1964562166 title "Vitamin D as an anti-microbial and anti-inflammatory therapy for Cystic Fibrosis" @default.
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