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- W1964562382 abstract "We wish to defend the kinetic-segregation (K-S) model of T-cell receptor (TCR) triggering [ 1 Davis S.J. van der Merwe P.A. The structure and ligand interactions of CD2: implications for T-cell function. Immunol. Today. 1996; 17: 177-187 Abstract Full Text PDF PubMed Scopus (341) Google Scholar , 2 van der Merwe P.A. et al. Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition. Semin. Immunol. 2000; 12: 5-21 Crossref PubMed Scopus (246) Google Scholar ] against several points raised by Trautmann and Randriamampita in their recent Opinion article on the initiation of TCR signalling [ 3 Trautmann A. Randriamampita C. Initiation of TCR signalling revisited. Trends Immunol. 2003; 24: 425-428 Abstract Full Text Full Text PDF PubMed Scopus (25) Google Scholar ]. The authors claim that the K-S model is weakened by apparently failing to account for co-receptor dependent signalling, is experimentally unsubstantiated and cannot explain the signalling effects of soluble MHC–peptide molecules." @default.
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- W1964562382 date "2003-12-01" @default.
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- W1964562382 title "TCR triggering: co-receptor-dependent or -independent?" @default.
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- W1964562382 doi "https://doi.org/10.1016/j.it.2003.10.009" @default.
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