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- W1964562854 abstract "The level of 2,3-diphosphoglycerate (2,3-DPG) in erythrocytes was found to be increased in patients with cirrhosis of the liver, and as a consequence the oxygen affinity of hemoglobin was decreased. Part of the 2,3-DPG increase in the patients with cirrhosis was caused by a concomitant anemia. At all hemoglobin levels, however, patients with cirrhosis showed an additional 2,3-DPG increase in comparison with patients without cirrhosis. Red cell 2,3-DPG was positively correlated to pH in plasma and in erythrolysate. It is likely that pH changes contribute to the regulation of the red cell 2,3-DPG concentration in cirrhotic patients. In a group of these patients (n=48), the arterial pH and pCO2 did not differ significantly from normal values. Other, as yet unknown, factors must presumably contribute to the increase in red cell 2,3-DPG. No direct effect of NH4+ on red cell 2,3-DPG could be demonstrated in vitro. The plasma concentration of NH4+ in vivo correlated positively to plasma pH. The lowered oxygen affinity does not contribute significantly to the decrease in oxygen saturation of arterial blood often found in patients with hepatic cirrhosis." @default.
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- W1964562854 date "1973-01-01" @default.
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- W1964562854 title "Oxygen Affinity of Hemoglobin and Red Cell 2,3-Diphosphoglycerate in Hepatic Cirrhosis" @default.
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- W1964562854 doi "https://doi.org/10.3109/00365517309082436" @default.
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