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• W1964564771 endingPage "2369" @default.
• W1964564771 startingPage "2360" @default.
• W1964564771 abstract "ABSTRACT SecA is an essential ATP-driven motor protein that binds to presecretory or membrane proteins and the translocon and promotes the translocation or membrane integration of these proteins. secA is subject to a protein secretion-specific form of regulation, whereby its translation is elevated during secretion-limiting conditions. A novel mechanism that promotes this regulation involves translational pausing within the gene upstream of secA , secM . The secM translational pause prevents formation of an RNA helix that normally blocks secA translational initiation. The duration of this pause is controlled by the rate of secretion of nascent SecM, which in turn depends on its signal peptide and a functional translocon. We characterized the atypical secM signal peptide and found that mutations within the amino-terminal region specifically affect the secM translational pause and secA regulation, while mutations in the hydrophobic core region affect SecM secretion as well as translational pausing and secA regulation. In addition, mutational analysis of the 3′ end of secM allowed us to identify a conserved region that is required to promote the translational pause that appears to be operative at the peptide level. Together, our results provide direct support for the secM translational pause model of secA regulation, and they pinpoint key sequences within secM that promote this important regulatory system." @default.
• W1964564771 created "2016-06-24" @default.
• W1964564771 creator A5045021053 @default.
• W1964564771 creator A5055074920 @default.
• W1964564771 date "2002-05-01" @default.
• W1964564771 modified "2023-10-12" @default.
• W1964564771 title "Critical Regions of <i>secM</i> That Control Its Translation and Secretion and Promote Secretion-Specific <i>secA</i> Regulation" @default.
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• W1964564771 doi "https://doi.org/10.1128/jb.184.9.2360-2369.2002" @default.
• W1964564771 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/134986" @default.
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