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• W1964571355 abstract "Inhibition studies with N-methylcarbamates and phenylureas were carried out to examine the mechanism for microsomal N-demethylation of substituted 3-(phenyl)-1-methylureas. Studies with a number of substituted N-methylcarbamates showed that a high electron density at the ortho position relative to the carbamate group was necessary for an effective inhibition of N-demethylation. Similar studies with several substituted phenylureas demonstrated that the proton on the aniline nitrogen atom was also necessary for effective inhibition of the microsomal N-demethylase system. Stable isotope studies with a methyl-d3 and a carbonyl-18O labeled 3-(phenyl)-1-methylurea were also performed; the methyl-d3 substrate exhibited a value of kH/kD = 1·3 for the metabolic reaction, and the carbonyl-18O substrate demonstrated no isotopic exchange of labeled oxygen after N-dealkylation." @default.
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• W1964571355 date "1972-09-01" @default.
• W1964571355 modified "2023-10-16" @default.
• W1964571355 title "Mechanism of oxidative N-demethylation by cotton microsomes" @default.
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• W1964571355 doi "https://doi.org/10.1016/s0031-9422(00)86500-0" @default.
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