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- W1964574055 abstract "CREB-responsive transcription has an important role in adaptive responses in all cells and tissue. In the nervous system, it has an essential and well established role in long-term memory formation throughout a diverse set of organisms. Activation of this transcription factor correlates with long-term memory formation and disruption of its activity interferes with this process. Most convincingly, augmenting CREB activity in a number of different systems enhances memory formation. In Drosophila, a sequence rearrangement in the original transgene used to enhance memory formation has been a source of confusion. This rearrangement prematurely terminates translation of the full-length protein, leaving the identity of the enhancing molecule unclear. In this report, we show that a naturally occurring, downstream, in-frame initiation codon is used to make a dCREB2 protein off of both transgenic and chromosomal substrates. This protein is a transcriptional activator and is responsible for memory enhancement. A number of parameters can affect enhancement, including the short-lived activity of the activator protein, and the time-of-day when induction and behavioral training occur. Our results reaffirm that overexpression of a dCREB2 activator can enhance memory formation and illustrate the complexity of this behavioral enhancement." @default.
- W1964574055 created "2016-06-24" @default.
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- W1964574055 date "2013-04-24" @default.
- W1964574055 modified "2023-09-27" @default.
- W1964574055 title "dCREB2-Mediated Enhancement of Memory Formation" @default.
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- W1964574055 doi "https://doi.org/10.1523/jneurosci.4387-12.2013" @default.
- W1964574055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3667961" @default.
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