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• W1964574920 abstract "The 58-kDa surface mannoprotein of Candida albicans (mp58) elicits strong antibody responses during infection. Epitope mapping with sera from patients with candidiasis and control individuals indicated the presence of multiple IgG-reactive continuous epitopes on the protein, expanding both the amino- and carboxy-terminal domains and several internal regions. These immunoreactive regions were similar to the ones previously identified using sera from immunized animals. Two of the epitopic regions (including the C-terminal domain) showed increased reactivity with antibodies present in sera from patients with candidiasis as compared to control individuals. Patients who survived the infection displayed increased antibody reactivity towards the C-terminal epitope as compared to those succumbing to candidiasis. A monoclonal antibody directed towards this epitopic region conferred protection in serum therapy experiments in a murine model of hematogenously disseminated candidiasis. Together, these observations indicate the carboxy-terminal antibody binding domain of C. albicans mp58 represents a protective epitope during candidiasis." @default.
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• W1964574920 date "2004-03-01" @default.
• W1964574920 modified "2023-10-18" @default.
• W1964574920 title "The C-terminal antibody binding domain of<i>Candida albicans</i>mp58 represents a protective epitope during candidiasis" @default.
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• W1964574920 doi "https://doi.org/10.1016/s0378-1097(04)00042-4" @default.
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