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- W1964579588 abstract "The CD4 molecule functions as a receptor for the binding and infectivity of the human immunodeficiency virus (HIV). It is of interest, therefore, to develop procedures for its down-regulation. In the present study, the effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the expression of cell surface antigens of the HL-60 promyelocytic leukemia cell line was analyzed. Exposure of HL-60 cells to 1,25(OH)2D3 resulted in down-regulation of CD4 as assessed by their staining with the Leu-3a monoclonal antibody (MoAb). This treatment increased the staining of HL-60 cells with the monocyte-specific 63D3 MoAb. In contrast to the rapid elimination of cell surface CD4 by exposure of HL-60 to phorbol myristate acetate (PMA), the maximal reduction of CD4 by 1,25(OH)2D3 was attained within 48 h after the beginning of the exposure." @default.
- W1964579588 created "2016-06-24" @default.
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- W1964579588 date "1989-10-01" @default.
- W1964579588 modified "2023-09-27" @default.
- W1964579588 title "Modulation of the expression of CD4 on HL-60 cells by exposure to 1,25-dihydroxyvitamin D3" @default.
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- W1964579588 doi "https://doi.org/10.1016/0165-2478(89)90170-3" @default.
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