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- W1964589324 abstract "Angiogenesis is a necessary process for tumor progression and is driven through molecular interactions between cancer cells and neighboring vascular endothelial cells. The primary mediators of angiogenesis are the vascular endothelial growth factors and their respective receptors on endothelial cells. There are several U.S. Food and Drug Administration-approved anti-angiogenic agents in clinical use. In head and neck cancer there are clinical trials assessing the efficacy of anti-angiogenic agents in combination with chemoradiation therapy. Although the aforementioned growth factors and receptors have been traditionally viewed as anti-angiogenic targets, there are concomitant efforts to understand the role these molecules play within the tumor cells. In this review, we first discuss the biology of angiogenic proteins and the targeting of angiogenic molecules for cancer treatment. We summarize the current clinical trials of anti-angiogenic therapies in head and neck squamous cell carcinoma. Finally, the additional role these molecules play in tumor progression independent of angiogenesis is discussed." @default.
- W1964589324 created "2016-06-24" @default.
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- W1964589324 creator A5026300491 @default.
- W1964589324 creator A5028189327 @default.
- W1964589324 creator A5071510209 @default.
- W1964589324 date "2010-12-16" @default.
- W1964589324 modified "2023-10-09" @default.
- W1964589324 title "Biology of vascular endothelial growth factor and its receptors in head and neck cancer: Beyond angiogenesis" @default.
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- W1964589324 doi "https://doi.org/10.1002/hed.21588" @default.
- W1964589324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21755565" @default.
- W1964589324 hasPublicationYear "2010" @default.
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