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• W1964589527 abstract "The insulinlike growth factor 1 receptor (IGF-1R) is a new target for the treatment of breast cancer. Patients with breast cancer lesions that express IGF-1R may benefit from treatment with anti–IGF-1R antibodies. Therefore, the aim of the present study was to develop a noninvasive, in vivo imaging method, using radiolabeled antibodies, to visualize IGF-1R expression. <b>Methods:</b> R1507 is a monoclonal antibody directed against the IGF-1R. In vitro, the affinity and internalization kinetics of ¹¹¹In-R1507 were determined using the IGF-1R–expressing triple-negative breast cancer cell line SUM149. In vivo, the pharmacodynamics of ¹¹¹In-R1507 and ¹²⁵I-R1507 were determined in mice with subcutaneous SUM149 tumors. ¹¹¹In-R1507 SPECT and ⁸⁹Zr-R1507 PET images of mice with subcutaneous SUM149 tumors were acquired at 1, 3, and 7 d after injection. <b>Results:</b>¹¹¹In-R1507 (concentration required to inhibit binding by 50%, 0.1 nM) was slowly internalized by SUM149 cells. ¹¹¹In-R1507 specifically and efficiently accumulated in the SUM149 xenografts: the tumor uptake was 20 percentage injected dose per gram (%ID/g), 33 %ID/g, and 31 %ID/g at 1, 3, and 7 d after injection, respectively. ¹²⁵I-R1507 accumulated in the tumor less efficiently. Small-animal SPECT and small-animal PET of mice clearly visualized the subcutaneous SUM149 xenograft, with increasing contrast at later time points. <b>Conclusion:</b>¹¹¹In-R1507 and ⁸⁹Zr-R1507 are new tracers to noninvasively determine IGF-1R expression in vivo in breast cancer xenografts using SPECT and PET. In the future, these techniques may enable patient selection for IGF-1R–targeted therapy." @default.
• W1964589527 created "2016-06-24" @default.
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• W1964589527 date "2010-09-16" @default.
• W1964589527 modified "2023-09-24" @default.
• W1964589527 title "ImmunoSPECT and ImmunoPET of IGF-1R Expression with the Radiolabeled Antibody R1507 in a Triple-Negative Breast Cancer Model" @default.
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• W1964589527 doi "https://doi.org/10.2967/jnumed.110.075648" @default.
• W1964589527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20847162" @default.
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