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- W1964591875 abstract "Immature double-positive thymocytes are generated in the thymic cortex, and on positive selection, are induced to differentiate into mature single-positive thymocytes and relocate to the medulla. CCR7 is pivotal for cortex-to-medulla migration of positively selected thymocytes, and CCR7-mediated migration to the medulla is essential for establishing central tolerance, thereby, preventing tissue-specific autoimmunity. However, it was unclear how CCR7-mediated migration to the medulla affects the establishment of self-tolerance. Here, we show that the deletion of thymocytes specific for insulin-promoter-driven tissue-restricted antigens (TRAs) is significantly impaired in CCR7- or CCR7-ligand-deficient mice. These results indicate that CCR7-mediated migration to the medulla contributes to the negative selection of TRA-reactive thymocytes." @default.
- W1964591875 created "2016-06-24" @default.
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- W1964591875 date "2009-10-06" @default.
- W1964591875 modified "2023-10-11" @default.
- W1964591875 title "CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens" @default.
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- W1964591875 doi "https://doi.org/10.1073/pnas.0906956106" @default.
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