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• W1964598242 abstract "Objective To test whether the association between childhood abuse, cannabis use and psychotic experiences ( PE s) was moderated by the COMT (catechol‐ O ‐methyltransferase) gene. Method Psychotic experiences ( PE s), childhood abuse, cannabis use and COMT Val158Met genotypes were assessed in 533 individuals from the general population. Data were analysed hierarchically by means of multiple linear regression models. Results Childhood abuse showed a significant main effect on both positive (β = 0.09; SE = 0.04; P = 0.047) and negative PE s (β = 0.11; SE = 0.05; P = 0.038). A significant three‐way interaction effect was found among childhood abuse, cannabis use and the COMT gene on positive PE s (β = −0.30; SE = 0.11; P = 0.006). This result suggests that COMT genotypes and cannabis use only influenced PE scores among individuals exposed to childhood abuse. Furthermore, exposure to childhood abuse and cannabis use increased PE scores in Val carriers. However, in individuals exposed to childhood abuse but who did not use cannabis, PE s increased as a function of the Met allele copies of the COMT gene. Conclusion Cannabis use after exposure to childhood abuse may have opposite effects on the risk of PE s, depending on the COMT genotypes providing evidence for a qualitative interaction. Val carriers exposed to childhood abuse are vulnerable to the psychosis‐inducing effects of cannabis." @default.
• W1964598242 created "2016-06-24" @default.
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• W1964598242 date "2013-02-28" @default.
• W1964598242 modified "2023-10-10" @default.
• W1964598242 title "Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes" @default.
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• W1964598242 doi "https://doi.org/10.1111/acps.12108" @default.
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