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- W1964601115 abstract "The present study was designed to investigate the effect of acute administration of gonadotropin on testicular steroid secretion in dog and rat. Animals received a subcutaneous injection of 25 IU/kg of hCG or 1.5 μg/kg of [d-Trp6, des-Gly-NH210]LHRH ethylamide (LHRH-A). Testosterone is the predominant steroid measured, in dog plasma, under basal conditions. After LHRH-A injection, testosterone levels are not significantly changed while dehydroepiandrosterone and androst-5-ene-3β,17β-diol (Δ5 steroids) levels are stimulated by almost 20-fold (P < 0.01). When dogs were injected with hCG, we also observed a marked stimulation of dehydroepiandrosterone levels (20-fold; P < 0.01) accompanied by a small increase of plasma testosterone concentration (2-fold, P < 0.01). In rats injected with either hCG or the LHRH analogue, an increment of plasma testosterone (7-fold, P < 0.01) is detected in the first hour while plasma dehydroepiandrosterone levels are slightly stimulated. Moreover, in rats injected with hCG, low plasma steroid levels are present between 4–12 h after injection due to testicular desensitization. This marked decrease is then followed by a second peak of steroid secretion 24 h later. Acute testicular steroidogenic responsiveness to hCG on the dog is, however, different: after stimulation, the levels of plasma dehydroepiandrosterone are maintained at a plateau and slowly decline after 24–48 h. Our data indicate that in dogs, stimulation of testicular steroidogenesis leads to an increase of plasma Δ5-steroid levels while the same stimuli cause, in the rat, a stimulation of Δ4-androgen, particularly testosterone." @default.
- W1964601115 created "2016-06-24" @default.
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- W1964601115 date "1985-03-01" @default.
- W1964601115 modified "2023-10-15" @default.
- W1964601115 title "Changes in plasma steroid levels after single administration of hCG or LHRH agonist analogue in dog and rat" @default.
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- W1964601115 doi "https://doi.org/10.1016/0022-4731(85)90432-7" @default.
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