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• W1964614037 abstract "Novobiocin analogs lacking labile glycosidic ether have been designed, synthesized and evaluated for Hsp90 inhibitory activity. Replacement of the synthetically complex noviose sugar with simple aromatic side chains produced analogs that maintain moderate cytotoxic activity against MCF7 and SkBR3 breast cancer cell-lines. Rationale for the preparation of des-noviose novobiocin analogs in addition to their synthesis and biological evaluation are presented herein." @default.
• W1964614037 created "2016-06-24" @default.
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• W1964614037 date "2011-12-01" @default.
• W1964614037 modified "2023-10-16" @default.
• W1964614037 title "Synthesis and biological evaluation of arylated novobiocin analogs as Hsp90 inhibitors" @default.
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• W1964614037 doi "https://doi.org/10.1016/j.bmcl.2011.09.073" @default.
• W1964614037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3242434" @default.
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