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- W1964616441 endingPage "536" @default.
- W1964616441 startingPage "528" @default.
- W1964616441 abstract "Malignant melanoma arises from epidermal melanocytes, the cells responsible for the production of the skin pigment melanin. The photoprotective role of melanin, which is transferred to neighboring keratinocytes, in UV-induced skin carcinogenesis, specifically in nonmelanoma skin cancers, has been well documented. Although melanocyte-resident melanin is expected to offer similar protection to melanocytes from UV-induced damage, UV radiation has long been suspected to have an etiologic role in cutaneous melanoma. However, nearly three decades of efforts using a variety of in vitro and in vivo models of human skin and mouse genetic models have produced conflicting data. Epidemiologic studies have also failed to establish a definitive association between UV exposure and risk of melanoma. In this review, we evaluate the dual role of the melanin pigment as a photoprotector as well as a photosensitizer and examine the evidence for association between melanin levels (constitutive and induced) and melanoma risk. We also discuss possible reasons for the lack of signature UV mutations in melanoma oncogenes known to date and potential alternative mechanisms to explain the role of UV in melanomagenesis." @default.
- W1964616441 created "2016-06-24" @default.
- W1964616441 creator A5025837205 @default.
- W1964616441 creator A5053390213 @default.
- W1964616441 date "2008-03-01" @default.
- W1964616441 modified "2023-10-05" @default.
- W1964616441 title "Role of UV in Cutaneous Melanoma" @default.
- W1964616441 cites W1270711560 @default.
- W1964616441 cites W1500051024 @default.
- W1964616441 cites W1570756865 @default.
- W1964616441 cites W1585626527 @default.
- W1964616441 cites W1591358050 @default.
- W1964616441 cites W1829156160 @default.
- W1964616441 cites W1964555738 @default.
- W1964616441 cites W1971050728 @default.
- W1964616441 cites W1971571835 @default.
- W1964616441 cites W1971866649 @default.
- W1964616441 cites W1974000457 @default.
- W1964616441 cites W1974119940 @default.
- W1964616441 cites W1976594116 @default.
- W1964616441 cites W1977538828 @default.
- W1964616441 cites W1978043873 @default.
- W1964616441 cites W1979276428 @default.
- W1964616441 cites W1980625127 @default.
- W1964616441 cites W1982442966 @default.
- W1964616441 cites W1982571441 @default.
- W1964616441 cites W1984293031 @default.
- W1964616441 cites W1986826106 @default.
- W1964616441 cites W1989121777 @default.
- W1964616441 cites W1991652104 @default.
- W1964616441 cites W1992294575 @default.
- W1964616441 cites W1993886329 @default.
- W1964616441 cites W1994776718 @default.
- W1964616441 cites W1995046561 @default.
- W1964616441 cites W1995076534 @default.
- W1964616441 cites W1996639067 @default.
- W1964616441 cites W1998728612 @default.
- W1964616441 cites W2003006686 @default.
- W1964616441 cites W2003051520 @default.
- W1964616441 cites W2006985041 @default.
- W1964616441 cites W2009632091 @default.
- W1964616441 cites W2011755139 @default.
- W1964616441 cites W2011950974 @default.
- W1964616441 cites W2014714862 @default.
- W1964616441 cites W2019368227 @default.
- W1964616441 cites W2020055953 @default.
- W1964616441 cites W2022497779 @default.
- W1964616441 cites W2025761890 @default.
- W1964616441 cites W2028973244 @default.
- W1964616441 cites W2031597608 @default.
- W1964616441 cites W2034516953 @default.
- W1964616441 cites W2036103078 @default.
- W1964616441 cites W2036671742 @default.
- W1964616441 cites W2038280196 @default.
- W1964616441 cites W2038511611 @default.
- W1964616441 cites W2039102830 @default.
- W1964616441 cites W2041848980 @default.
- W1964616441 cites W2043292995 @default.
- W1964616441 cites W2045484140 @default.
- W1964616441 cites W2048215988 @default.
- W1964616441 cites W2048440231 @default.
- W1964616441 cites W2049311151 @default.
- W1964616441 cites W2050226284 @default.
- W1964616441 cites W2052872443 @default.
- W1964616441 cites W2055575745 @default.
- W1964616441 cites W2056826119 @default.
- W1964616441 cites W2057137683 @default.
- W1964616441 cites W2058372909 @default.
- W1964616441 cites W2060188416 @default.
- W1964616441 cites W2060573548 @default.
- W1964616441 cites W2063730964 @default.
- W1964616441 cites W2063764814 @default.
- W1964616441 cites W2064487643 @default.
- W1964616441 cites W2067284736 @default.
- W1964616441 cites W2068885582 @default.
- W1964616441 cites W2073142030 @default.
- W1964616441 cites W2073549690 @default.
- W1964616441 cites W2074895307 @default.
- W1964616441 cites W2075370172 @default.
- W1964616441 cites W2077403011 @default.
- W1964616441 cites W2078587953 @default.
- W1964616441 cites W2080349213 @default.
- W1964616441 cites W2087224165 @default.
- W1964616441 cites W2087406053 @default.
- W1964616441 cites W2090201014 @default.
- W1964616441 cites W2091720683 @default.
- W1964616441 cites W2093124195 @default.
- W1964616441 cites W2095043845 @default.
- W1964616441 cites W2098430250 @default.
- W1964616441 cites W2107461091 @default.
- W1964616441 cites W2107662850 @default.
- W1964616441 cites W2108394393 @default.
- W1964616441 cites W2111054184 @default.
- W1964616441 cites W2111108112 @default.
- W1964616441 cites W2112467050 @default.
- W1964616441 cites W2115693635 @default.
- W1964616441 cites W2116415841 @default.
- W1964616441 cites W2116933611 @default.