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• W1964623776 endingPage "150" @default.
• W1964623776 startingPage "140" @default.
• W1964623776 abstract "To gain a better understanding of the role of specific numerical and structural chromosome changes in the multistage process of transformation of Syrian hamster embryo (SHE) cells, we analyzed seven benzo(a)pyrene (BP)-induced immortal SHE cell lines, and one spontaneously immortalized cell line. In addition, we analyzed chromosome changes in early passage tumor-derived cell lines induced by injection of four immortalized cell lines into neonate hamsters. Of particular interest was the observation of a deletion in the short arm of chromosome 2 in four of the seven BP-immortalized cell lines. Other types of alterations in chromosome 2 were observed in two other cell lines. Loss of one copy of chromosome 16 was also observed in more than 90 to 100% of the cells in three of seven BP-immortalized cell lines. In contrast, the only chromosome alteration seen in the spontaneously immortalized cell line was a deletion in the short arm of chromosome 20. Genetic instability, as indicated by increased numerical or structural chromosome changes, was observed in all tumor-derived cell lines compared to the immortal cell line from which they originated. These results, along with previous reports in the literature, suggest that alterations in specific chromosomes, like chromosome 2, may be involved in transformation of SHE cells." @default.
• W1964623776 created "2016-06-24" @default.
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• W1964623776 date "1997-07-01" @default.
• W1964623776 modified "2023-09-26" @default.
• W1964623776 title "Aneuploidy and Consistent Structural Chromosome Changes Associated with Transformation of Syrian Hamster Embryo Cells" @default.
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• W1964623776 doi "https://doi.org/10.1016/s0165-4608(96)00301-9" @default.
• W1964623776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9216722" @default.
• W1964623776 hasPublicationYear "1997" @default.
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