Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964624871> ?p ?o ?g. }
- W1964624871 endingPage "51" @default.
- W1964624871 startingPage "45" @default.
- W1964624871 abstract "With the growing aging population in Western countries, Alzheimer's disease (AD) has become a major public health concern. No preventive measure and effective treatment for this burdensome disease is currently available. Genetic, biochemical, and neuropathological data strongly suggest that Abeta amyloidosis, which originates from the amyloidogenic processing of a metalloprotein-amyloid precursor protein (APP), is the key event in AD pathology. However, neurochemical factors that impact upon the age-dependent cerebral Abeta amyloidogenesis are not well recognized. Growing data indicate that cerebral dysregulation of biometals, environmental metal exposure, and oxidative stress contribute to AD pathology. Herein we provided further evidence that both metals (such as Cu) and H(2)O(2) promote formation of neurotoxic Abeta oligomers. Moreover, we first demonstrated that laser capture microdissection coupled with X-ray fluorescence microscopy can be applied to determine elemental profiles (S, Fe, Cu, and Zn) in Abeta amyloid plaques. Clearly the fundamental biochemical mechanisms linking brain biometal metabolism, environmental metal exposure, and AD pathophysiology warrant further investigation. Nevertheless, the study of APP and Abeta metallobiology may identify potential targets for therapeutic intervention and/or provide diagnostic methods for AD." @default.
- W1964624871 created "2016-06-24" @default.
- W1964624871 creator A5007938241 @default.
- W1964624871 creator A5008045674 @default.
- W1964624871 creator A5008848229 @default.
- W1964624871 creator A5027446790 @default.
- W1964624871 creator A5040726643 @default.
- W1964624871 creator A5050004777 @default.
- W1964624871 creator A5059958623 @default.
- W1964624871 creator A5069404815 @default.
- W1964624871 creator A5080825168 @default.
- W1964624871 date "2006-07-01" @default.
- W1964624871 modified "2023-10-02" @default.
- W1964624871 title "Metal exposure and Alzheimer’s pathogenesis" @default.
- W1964624871 cites W1465603094 @default.
- W1964624871 cites W1484784716 @default.
- W1964624871 cites W1963680576 @default.
- W1964624871 cites W1963712466 @default.
- W1964624871 cites W1973637060 @default.
- W1964624871 cites W1977813572 @default.
- W1964624871 cites W1978254707 @default.
- W1964624871 cites W1978842877 @default.
- W1964624871 cites W1981570625 @default.
- W1964624871 cites W1982063629 @default.
- W1964624871 cites W1985348492 @default.
- W1964624871 cites W1996579240 @default.
- W1964624871 cites W1996735580 @default.
- W1964624871 cites W2005881537 @default.
- W1964624871 cites W2009833553 @default.
- W1964624871 cites W2017550829 @default.
- W1964624871 cites W2018333394 @default.
- W1964624871 cites W2018753627 @default.
- W1964624871 cites W2020538411 @default.
- W1964624871 cites W2023489048 @default.
- W1964624871 cites W2025944561 @default.
- W1964624871 cites W2032920422 @default.
- W1964624871 cites W2033017137 @default.
- W1964624871 cites W2037387044 @default.
- W1964624871 cites W2041230020 @default.
- W1964624871 cites W2046847750 @default.
- W1964624871 cites W2051516838 @default.
- W1964624871 cites W2052120254 @default.
- W1964624871 cites W2052987925 @default.
- W1964624871 cites W2054113864 @default.
- W1964624871 cites W2056046302 @default.
- W1964624871 cites W2061500679 @default.
- W1964624871 cites W2063281989 @default.
- W1964624871 cites W2069682857 @default.
- W1964624871 cites W2075420978 @default.
- W1964624871 cites W2079722596 @default.
- W1964624871 cites W2081881251 @default.
- W1964624871 cites W2082504479 @default.
- W1964624871 cites W2083500052 @default.
- W1964624871 cites W2083715632 @default.
- W1964624871 cites W2088997949 @default.
- W1964624871 cites W2093499884 @default.
- W1964624871 cites W2094411486 @default.
- W1964624871 cites W2094808560 @default.
- W1964624871 cites W2096410114 @default.
- W1964624871 cites W2107225636 @default.
- W1964624871 cites W2109847775 @default.
- W1964624871 cites W2112633282 @default.
- W1964624871 cites W2114518943 @default.
- W1964624871 cites W2120937046 @default.
- W1964624871 cites W2121963977 @default.
- W1964624871 cites W2124866182 @default.
- W1964624871 cites W2129489564 @default.
- W1964624871 cites W2131633241 @default.
- W1964624871 cites W2131819352 @default.
- W1964624871 cites W2133324295 @default.
- W1964624871 cites W2138417832 @default.
- W1964624871 cites W2141150496 @default.
- W1964624871 cites W2143546229 @default.
- W1964624871 cites W2145901639 @default.
- W1964624871 cites W2150999725 @default.
- W1964624871 cites W2157359173 @default.
- W1964624871 cites W2157935345 @default.
- W1964624871 cites W2165021720 @default.
- W1964624871 cites W2169152986 @default.
- W1964624871 doi "https://doi.org/10.1016/j.jsb.2005.12.011" @default.
- W1964624871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16503166" @default.
- W1964624871 hasPublicationYear "2006" @default.
- W1964624871 type Work @default.
- W1964624871 sameAs 1964624871 @default.
- W1964624871 citedByCount "121" @default.
- W1964624871 countsByYear W19646248712012 @default.
- W1964624871 countsByYear W19646248712013 @default.
- W1964624871 countsByYear W19646248712014 @default.
- W1964624871 countsByYear W19646248712015 @default.
- W1964624871 countsByYear W19646248712017 @default.
- W1964624871 countsByYear W19646248712018 @default.
- W1964624871 countsByYear W19646248712019 @default.
- W1964624871 countsByYear W19646248712020 @default.
- W1964624871 countsByYear W19646248712021 @default.
- W1964624871 countsByYear W19646248712022 @default.
- W1964624871 countsByYear W19646248712023 @default.
- W1964624871 crossrefType "journal-article" @default.
- W1964624871 hasAuthorship W1964624871A5007938241 @default.