FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964627775> ?p ?o ?g. }

• W1964627775 abstract "Free-living planarian flatworms have a long history of experimental usage owing to their remarkable regenerative abilities. Small fragments excised from these animals reform the original body plan following regeneration of missing body structures. For example if a 'trunk' fragment is cut from an intact worm, a new 'head' will regenerate anteriorly and a 'tail' will regenerate posteriorly restoring the original 'head-to-tail' polarity of body structures prior to amputation. Regeneration is driven by planarian stem cells, known as 'neoblasts' which differentiate into ~30 different cell types during normal body homeostasis and enforced tissue regeneration. This regenerative process is robust and easy to demonstrate. Owing to the dedication of several pioneering labs, many tools and functional genetic methods have now been optimized for this model system. Consequently, considerable recent progress has been made in understanding and manipulating the molecular events underpinning planarian developmental plasticity. The planarian model system will be of interest to a broad range of scientists. For neuroscientists, the model affords the opportunity to study the regeneration of an entire nervous system, rather than simply the regrowth/repair of single nerve cell process that typically are the focus of study in many established models. Planarians express a plethora of neurotransmitters, represent an important system for studying evolution of the central nervous system and have behavioral screening potential. Regenerative outcomes are amenable to manipulation by pharmacological and genetic apparoaches. For example, drugs can be screened for effects on regeneration simply by placing body fragments in drug-containing solutions at different time points after amputation. The role of individual genes can be studied using knockdown methods (in vivo RNAi), which can be achieved either through cycles of microinjection or by feeding bacterially-expressed dsRNA constructs. Both approaches can produce visually striking phenotypes at high penetrance--for example, regeneration of bipolar animals. To facilitate adoption of this model and implementation of such methods, we showcase in this video article protocols for pharmacological and genetic assays (in vivo RNAi by feeding) using the planarian Dugesia japonica." @default.
• W1964627775 created "2016-06-24" @default.
• W1964627775 creator A5008962065 @default.
• W1964627775 creator A5047013622 @default.
• W1964627775 date "2011-08-31" @default.
• W1964627775 modified "2023-09-30" @default.
• W1964627775 title "Pharmacological and Functional Genetic Assays to Manipulate Regeneration of the Planarian <em>Dugesia japonica</em>" @default.
• W1964627775 cites W1964005948 @default.
• W1964627775 cites W1971481058 @default.
• W1964627775 cites W1977398151 @default.
• W1964627775 cites W1997389247 @default.
• W1964627775 cites W2009530575 @default.
• W1964627775 cites W2023719014 @default.
• W1964627775 cites W2026641296 @default.
• W1964627775 cites W2037798895 @default.
• W1964627775 cites W2050039053 @default.
• W1964627775 cites W2066972948 @default.
• W1964627775 cites W2072572526 @default.
• W1964627775 cites W2076499916 @default.
• W1964627775 cites W2085407041 @default.
• W1964627775 cites W2093427063 @default.
• W1964627775 cites W2094255857 @default.
• W1964627775 cites W2094774123 @default.
• W1964627775 cites W2107498377 @default.
• W1964627775 cites W2111984642 @default.
• W1964627775 cites W2131359370 @default.
• W1964627775 cites W2136399909 @default.
• W1964627775 cites W2143721749 @default.
• W1964627775 cites W2146557306 @default.
• W1964627775 cites W2153321121 @default.
• W1964627775 cites W2168257801 @default.
• W1964627775 doi "https://doi.org/10.3791/3058" @default.
• W1964627775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3217636" @default.
• W1964627775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21897362" @default.
• W1964627775 hasPublicationYear "2011" @default.
• W1964627775 type Work @default.
• W1964627775 sameAs 1964627775 @default.
• W1964627775 citedByCount "11" @default.
• W1964627775 countsByYear W19646277752013 @default.
• W1964627775 countsByYear W19646277752014 @default.
• W1964627775 countsByYear W19646277752016 @default.
• W1964627775 countsByYear W19646277752017 @default.
• W1964627775 countsByYear W19646277752018 @default.
• W1964627775 countsByYear W19646277752019 @default.
• W1964627775 countsByYear W19646277752020 @default.
• W1964627775 countsByYear W19646277752023 @default.
• W1964627775 crossrefType "journal-article" @default.
• W1964627775 hasAuthorship W1964627775A5008962065 @default.
• W1964627775 hasAuthorship W1964627775A5047013622 @default.
• W1964627775 hasConcept C104317684 @default.
• W1964627775 hasConcept C105702510 @default.
• W1964627775 hasConcept C10854531 @default.
• W1964627775 hasConcept C111919701 @default.
• W1964627775 hasConcept C148737382 @default.
• W1964627775 hasConcept C169760540 @default.
• W1964627775 hasConcept C171056886 @default.
• W1964627775 hasConcept C196843134 @default.
• W1964627775 hasConcept C19843653 @default.
• W1964627775 hasConcept C2775935104 @default.
• W1964627775 hasConcept C2777113906 @default.
• W1964627775 hasConcept C2780205056 @default.
• W1964627775 hasConcept C28328180 @default.
• W1964627775 hasConcept C41008148 @default.
• W1964627775 hasConcept C54355233 @default.
• W1964627775 hasConcept C86803240 @default.
• W1964627775 hasConcept C95444343 @default.
• W1964627775 hasConcept C98045186 @default.
• W1964627775 hasConceptScore W1964627775C104317684 @default.
• W1964627775 hasConceptScore W1964627775C105702510 @default.
• W1964627775 hasConceptScore W1964627775C10854531 @default.
• W1964627775 hasConceptScore W1964627775C111919701 @default.
• W1964627775 hasConceptScore W1964627775C148737382 @default.
• W1964627775 hasConceptScore W1964627775C169760540 @default.
• W1964627775 hasConceptScore W1964627775C171056886 @default.
• W1964627775 hasConceptScore W1964627775C196843134 @default.
• W1964627775 hasConceptScore W1964627775C19843653 @default.
• W1964627775 hasConceptScore W1964627775C2775935104 @default.
• W1964627775 hasConceptScore W1964627775C2777113906 @default.
• W1964627775 hasConceptScore W1964627775C2780205056 @default.
• W1964627775 hasConceptScore W1964627775C28328180 @default.
• W1964627775 hasConceptScore W1964627775C41008148 @default.
• W1964627775 hasConceptScore W1964627775C54355233 @default.
• W1964627775 hasConceptScore W1964627775C86803240 @default.
• W1964627775 hasConceptScore W1964627775C95444343 @default.
• W1964627775 hasConceptScore W1964627775C98045186 @default.
• W1964627775 hasIssue "54" @default.
• W1964627775 hasLocation W19646277751 @default.
• W1964627775 hasLocation W19646277752 @default.
• W1964627775 hasOpenAccess W1964627775 @default.
• W1964627775 hasPrimaryLocation W19646277751 @default.
• W1964627775 hasRelatedWork W1971481058 @default.
• W1964627775 hasRelatedWork W1992663358 @default.
• W1964627775 hasRelatedWork W2037798895 @default.
• W1964627775 hasRelatedWork W2049730122 @default.
• W1964627775 hasRelatedWork W2056914231 @default.
• W1964627775 hasRelatedWork W2078730126 @default.
• W1964627775 hasRelatedWork W2094255857 @default.
• W1964627775 hasRelatedWork W2094774123 @default.
• W1964627775 hasRelatedWork W2106740149 @default.
• W1964627775 hasRelatedWork W2111984642 @default.

• next