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• W1964629897 abstract "DNA double-strand breaks (DSBs) are arguably the most important lesions induced by ionizing radiation (IR) since unrepaired or mis-repaired DSBs can lead to chromosomal aberrations and cell death. The two major pathways to repair IR-induced DSBs are non-homologous end-joining (NHEJ) and homologous recombination (HR). Perhaps surprisingly, NHEJ represents the predominant pathway in the G1 and G2 phases of the cell cycle, but HR also contributes and repairs a subset of IR-induced DSBs in G2. Following S-phase-dependent genotoxins, HR events give rise to sister chromatid exchanges (SCEs), which can be detected cytogenetically in mitosis. Here, we describe that HR occurring in G2-irradiated cells also generates SCEs in ~50% of HR events. Since HR of IR-induced DSBs in G2 is a slow process, SCE formation in G2-irradiated cells requires several hours. During this time, irradiated S-phase cells can also reach mitosis, which has contributed to the widely held belief that SCEs form only during S phase. We describe procedures to measure SCEs exclusively in G2-irradiated cells and provide evidence that following IR cells do not need to progress through S phase in order to form SCEs." @default.
• W1964629897 created "2016-06-24" @default.
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• W1964629897 creator A5050401892 @default.
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• W1964629897 date "2011-01-15" @default.
• W1964629897 modified "2023-10-17" @default.
• W1964629897 title "Sister chromatid exchanges occur in G₂-irradiated cells" @default.
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• W1964629897 doi "https://doi.org/10.4161/cc.10.2.14639" @default.
• W1964629897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3048794" @default.
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• W1964629897 hasPublicationYear "2011" @default.
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