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• W1964630724 abstract "The aim was to study the effects of an NMDA receptor antagonist on caspase-3 activation and DNA fragmentation after hypoxia-ischemia (HI) in 7-day-old rats. Animals were treated with vehicle or MK-801 (0.5 mg/kg) directly after HI and sacrificed 8, 24 or 72h later. MK-801 reduced injury (by 53%), cells positive for active caspase-3 (by 39%) and DNA fragmentation (by 79%) in the cerebral cortex. Furthermore, MK-801 significantly decreased caspase-3 activity, and Western blots revealed a tendency towards decreased proteolytic cleavage of the caspase-3 proform. The data imply that NMDA receptors are involved in the activation of apoptotic processes in the immature brain after HI." @default.
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• W1964630724 date "2000-09-01" @default.
• W1964630724 modified "2023-10-10" @default.
• W1964630724 title "NMDA blockade attenuates caspase-3 activation and DNA fragmentation after neonatal hypoxia–ischemia" @default.
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• W1964630724 doi "https://doi.org/10.1097/00001756-200009110-00002" @default.
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