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- W1964654376 abstract "ABSTRACT Heart failure treatment currently centers on symptom management, primarily through reductions in systemic blood pressure and fluid retention. The O-linked attachment of β-N-acetylglucosamine to cardiac proteins is increased in cardiovascular disease and heart failure, and O-GlcNAc transferase (OGT) is the enzyme that catalyzes this addition. Deletion of OGT is embryonically lethal, and cardiomyocyte-specific OGT knockdown causes the exacerbation of heart failure. Stem cell therapy is currently a major focus of heart failure research, and it was recently discovered that OGT is intricately involved with stem cell differentiation. This article focuses on the relationship of OGT with epigenetics and pluripotency, and integrates OGT with several emerging areas of heart failure research, including calcium signaling." @default.
- W1964654376 created "2016-06-24" @default.
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- W1964654376 date "2014-11-01" @default.
- W1964654376 modified "2023-09-23" @default.
- W1964654376 title "The role of O-GlcNAc transferase in regulating the gene transcription of developing and failing hearts" @default.
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- W1964654376 doi "https://doi.org/10.2217/fca.14.42" @default.
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