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- W1964655087 abstract "Acute and subacute toxicity studies were conducted with paraquat (1,1′-dimethyl-4,4′-dipyridylium dimethylsulfate) in adult Sherman rats. The single-dose oral LD50 was 100 mg/kg in male rats and 110 mg/kg in females. The 90-dose oral LD50 in female rats was 21 mg/kg, giving a chronicity factor of 5.2. The acute dermal LD50 was 80 mg/kg in male rats and 90 mg/kg in females. Studies of lung tissue with the electron microscope after a single oral dose indicate that the first discernible changes are pulmonary edema, swelling of the epithelium, an increase in collagen, and an effect on the ribosomes of the membranous pneumocytes. Light microscopic studies of lungs affected by paraquat after po and iv administration or local instillation showed intra-alveolar hemorrhage, edema, extensive fibrosis, and changes in the epithelium. Local instillation of 0.05 mg/kg of paraquat into lung and 0.8 mg/kg into skeletal muscle caused local fibrosis." @default.
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- W1964655087 date "1970-11-01" @default.
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- W1964655087 title "Toxicity of paraquat to rats and its effect on rat lungs" @default.
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- W1964655087 doi "https://doi.org/10.1016/0041-008x(70)90042-6" @default.
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