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• W1964662783 startingPage "125" @default.
• W1964662783 abstract "The amino acid sequence of human thyroglobulin is known to enclose cysteine-rich repetitive regions. In this study, we report the existence of an eleventh type-1 repeat within the human thyroglobulin sequence, and we characterize the thyroglobulin type-1 repeat as a protein module. The 11 thyroglobulin type-1 repeats possessed the same number of cysteine residues (six in type A, four in the two type B repeats), a fairly constant number of residues between cysteines and a conserved sequence pattern. By scanning protein sequence databases, 29 proteins belonging to six different families were found to enclose at least one, and up to three, thyroglobulin type-1 repeats in their sequence. Although the repeat was present in numerous proteins possessing binding properties, an examination of the information available in the literature showed that a direct role of the repeat in protein-protein interaction has rarely been assessed. A distance analysis of the sequences indicated that all repeats segregate into four clusters of phylogenically close sequences. A consensus sequence of type-1 repeats was derived from sequence similarity analysis; it comprised a central core of conserved residues including two highly conserved motifs, QC and CWCV. The type-1 repeat from thyroglobulin was found to differ from several previously described cysteine-rich modules, in particular from the epidermal-growth-factor-like module with which it has sometimes been confused. Therefore, our results provide a complete characterization of the repeats which will help in the detection of these repeats in newly characterized proteins, a necessary step for understanding the structural/biological role of this module." @default.
• W1964662783 created "2016-06-24" @default.
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• W1964662783 date "1996-08-01" @default.
• W1964662783 modified "2023-10-13" @default.
• W1964662783 title "Characterization of the Type-1 Repeat from Thyroglobulin, a Cysteine-Rich Module Found in Proteins from Different Families" @default.
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• W1964662783 doi "https://doi.org/10.1111/j.1432-1033.1996.0125h.x" @default.
• W1964662783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8797845" @default.
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