FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964680364> ?p ?o ?g. }

• W1964680364 endingPage "7851" @default.
• W1964680364 startingPage "7846" @default.
• W1964680364 abstract "The effects of Escherichia coli heat-stable enterotoxin (ST) and uroguanylin were examined on the proliferation of T84 and Caco2 human colon carcinoma cells that express guanylyl cyclase C (GC-C) and SW480 human colon carcinoma cells that do not express this receptor. ST or uroguanylin inhibited proliferation of T84 and Caco2 cells, but not SW480 cells, in a concentration-dependent fashion, assessed by quantifying cell number, cell protein, and [ 3 H]thymidine incorporation into DNA. These agonists did not inhibit proliferation by induction of apoptosis, assessed by TUNEL (terminal deoxynucleotidyl transferase-mediated dNTP-biotin nick end labeling of DNA fragments) assay and DNA laddering, or necrosis, assessed by trypan blue exclusion and lactate dehydrogenase release. Rather, ST prolonged the cell cycle, assessed by flow cytometry and [ 3 H]thymidine incorporation into DNA. The cytostatic effects of GC-C agonists were associated with accumulation of intracellular cGMP, mimicked by the cell-permeant analog 8-Br-cGMP, and reproduced and potentiated by the cGMP-specific phosphodiesterase inhibitor zaprinast but not the inactive ST analog TJU 1-103. Thus, GC-C agonists regulate the proliferation of intestinal cells through cGMP-dependent mechanisms by delaying progression of the cell cycle. These data suggest that endogenous agonists of GC-C, such as uroguanylin, may play a role in regulating the balance between epithelial proliferation and differentiation in normal intestinal physiology. Therefore, GC-C ligands may be novel therapeutic agents for the treatment of patients with colorectal cancer." @default.
• W1964680364 created "2016-06-24" @default.
• W1964680364 creator A5007902683 @default.
• W1964680364 creator A5022300126 @default.
• W1964680364 creator A5031301871 @default.
• W1964680364 creator A5036674274 @default.
• W1964680364 creator A5062664304 @default.
• W1964680364 date "2001-07-03" @default.
• W1964680364 modified "2023-10-16" @default.
• W1964680364 title "Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells" @default.
• W1964680364 cites W1497376376 @default.
• W1964680364 cites W1531895406 @default.
• W1964680364 cites W1535267589 @default.
• W1964680364 cites W1580648795 @default.
• W1964680364 cites W1602546631 @default.
• W1964680364 cites W1963640994 @default.
• W1964680364 cites W1964541624 @default.
• W1964680364 cites W1966210234 @default.
• W1964680364 cites W1969401721 @default.
• W1964680364 cites W1970678725 @default.
• W1964680364 cites W1982486162 @default.
• W1964680364 cites W1991513150 @default.
• W1964680364 cites W1998904527 @default.
• W1964680364 cites W2021772180 @default.
• W1964680364 cites W2031845865 @default.
• W1964680364 cites W2031965441 @default.
• W1964680364 cites W2033902055 @default.
• W1964680364 cites W2040046109 @default.
• W1964680364 cites W2042870085 @default.
• W1964680364 cites W2044813579 @default.
• W1964680364 cites W2047288220 @default.
• W1964680364 cites W2048386394 @default.
• W1964680364 cites W2050917247 @default.
• W1964680364 cites W2054302348 @default.
• W1964680364 cites W2057532838 @default.
• W1964680364 cites W2070038803 @default.
• W1964680364 cites W2077336138 @default.
• W1964680364 cites W2081508398 @default.
• W1964680364 cites W2089511085 @default.
• W1964680364 cites W2091368567 @default.
• W1964680364 cites W2094600730 @default.
• W1964680364 cites W2095353164 @default.
• W1964680364 cites W2105657039 @default.
• W1964680364 cites W2124063036 @default.
• W1964680364 cites W2126652357 @default.
• W1964680364 cites W2133970318 @default.
• W1964680364 cites W2136380442 @default.
• W1964680364 cites W2138302361 @default.
• W1964680364 cites W2145624386 @default.
• W1964680364 cites W2155836481 @default.
• W1964680364 cites W2156881931 @default.
• W1964680364 cites W2161011319 @default.
• W1964680364 cites W2163318604 @default.
• W1964680364 cites W2163431702 @default.
• W1964680364 cites W2166548168 @default.
• W1964680364 cites W2170187489 @default.
• W1964680364 cites W2178737721 @default.
• W1964680364 cites W233674973 @default.
• W1964680364 cites W2408762658 @default.
• W1964680364 cites W2438492624 @default.
• W1964680364 cites W2473516778 @default.
• W1964680364 cites W4290769925 @default.
• W1964680364 doi "https://doi.org/10.1073/pnas.141124698" @default.
• W1964680364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/35430" @default.
• W1964680364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11438734" @default.
• W1964680364 hasPublicationYear "2001" @default.
• W1964680364 type Work @default.
• W1964680364 sameAs 1964680364 @default.
• W1964680364 citedByCount "153" @default.
• W1964680364 countsByYear W19646803642012 @default.
• W1964680364 countsByYear W19646803642013 @default.
• W1964680364 countsByYear W19646803642014 @default.
• W1964680364 countsByYear W19646803642015 @default.
• W1964680364 countsByYear W19646803642016 @default.
• W1964680364 countsByYear W19646803642017 @default.
• W1964680364 countsByYear W19646803642018 @default.
• W1964680364 countsByYear W19646803642019 @default.
• W1964680364 countsByYear W19646803642020 @default.
• W1964680364 countsByYear W19646803642021 @default.
• W1964680364 countsByYear W19646803642022 @default.
• W1964680364 crossrefType "journal-article" @default.
• W1964680364 hasAuthorship W1964680364A5007902683 @default.
• W1964680364 hasAuthorship W1964680364A5022300126 @default.
• W1964680364 hasAuthorship W1964680364A5031301871 @default.
• W1964680364 hasAuthorship W1964680364A5036674274 @default.
• W1964680364 hasAuthorship W1964680364A5062664304 @default.
• W1964680364 hasBestOaLocation W19646803641 @default.
• W1964680364 hasConcept C153911025 @default.
• W1964680364 hasConcept C155878803 @default.
• W1964680364 hasConcept C185592680 @default.
• W1964680364 hasConcept C190283241 @default.
• W1964680364 hasConcept C29537977 @default.
• W1964680364 hasConcept C31573885 @default.
• W1964680364 hasConcept C43759708 @default.
• W1964680364 hasConcept C55493867 @default.
• W1964680364 hasConcept C62112901 @default.
• W1964680364 hasConcept C86803240 @default.
• W1964680364 hasConcept C95444343 @default.

• next