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- W1964682425 abstract "<i>Background:</i> There is considerable interest in using continuous venovenous hemofiltration machines for plasma exchange therapy in children. <i>Methods:</i> Retrospective study of 7 patients and 61 plasma exchange treatments using the Baxter/Edwards Lifesciences BM25 machine with commercially available plasma filters (mostly Asahi Plasmaflo). <i>Results:</i> The average total exchange volume was 1.5 times the plasma volume, achieved at a blood flow rate of 100 ml/m<sup>2</sup> (3.5 ml/kg/min) and a turnover rate of 25 ml/kg/h over a 3-hour duration. Fifty-six percent of the time, a mean heparin bolus of 29 units/kg resulted in subtherapeutic activated clotting times. Mean heparin infusion rates of 35 units of heparin/kg/h achieved effective anticoagulation. A calcium infusion rate of 0.11 ± 0.05 mmol/kg/h avoided hypocalcemia. One patient experienced the serious complication of membrane reaction. <i>Conclusions:</i> This setup provides a safe approach to plasma exchange in children. A similar method could be implemented in other centers." @default.
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- W1964682425 date "2005-01-01" @default.
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- W1964682425 title "Plasma Exchange Using a Continuous Venovenous Hemofiltration Machine in Children" @default.
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- W1964682425 doi "https://doi.org/10.1159/000088215" @default.
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