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- W1964693886 abstract "In the present study, we have analyzed the appearance and maturation of <em>γ/δ</em> T cells, recognized with a new mAb V65, in the central and peripheral lymphoid organs of fetal, neonatal, and adult Wistar rats. Cytofluorometrical analysis demonstrated the first V65<sup>+</sup><em>γ/δ</em> T cells in the thymus of 16-17-day embryonic rats, although by immunohistology, they were identified only in 19-day rat embryos in both the cortico-medullary border and thymic medulla. Phenotypically, <em>γ/δ</em> thymocytes from fetal and neonatal thymus expressed CD3, CD2, and CD5, but only 60-80% were CD8<sup>+</sup> and approximately 40-50% expressed the <em>α</em> chain (p55) of the IL-2R. In the periphery, the immunohistological study identified for the first time ,<em>γ/δ</em> T cells in the splenic white pulp and the gut of 21-day fetal rats, where they occurred within the epithelium as well as in the lamina propria. After birth, <em>γ/δ</em> lymphocytes appeared in the skin, where they were present as dendritic epidermal T cells in increasing numbers during postnatal life. Whereas these <em>γ/δ</em> T cells formed the predominant T-cell population in the rat skin, <em>γ/δ</em> T cells in peripheral lymphoid organs, BALT, or the gut only represented a minor T-cell population. These results are discussed in comparison to <em>γ/δ</em> T cells of other vertebrate species." @default.
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- W1964693886 date "1995-01-01" @default.
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- W1964693886 title "γ/δ Cells in Fetal, Neonatal, and Adult Rat Lymphoid Organs" @default.
- W1964693886 doi "https://doi.org/10.1155/1995/73127" @default.
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