FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964696307> ?p ?o ?g. }

• W1964696307 endingPage "90" @default.
• W1964696307 startingPage "84" @default.
• W1964696307 abstract "<i>Objectives:</i> Experimental data and case reports of patients with intractable epilepsy treated with deep brain stimulation (DBS) of the subthalamic nucleus (STN) suggest a considerable anticonvulsant effect. However, no satisfactory mechanisms of action have yet been elucidated. We investigated the putative therapeutic mechanisms of DBS from cerebral perfusion changes as measured by subtracting the SPECT image of the pre-DBS period from that of the chronic post-DBS state. <i>Methods:</i> Two patients who had previous resective surgery on their right frontal cortices with or without anterior callosotomy were selected for DBS of the STN. Both of them showed frequent bilateral asymmetric tonic seizures (left > right) with rare drop attacks, and 1 patient’s seizure frequency was more than 15/month during the pre-DBS period. They had both taken more than four antiepileptic agents for more than 10 years. After video-EEG monitoring, the irritative zones of the brain were delineated. The regional cerebral blood flow (rCBF) changes between the two SPECT images (pre-DBS and post-DBS after at least 6 months) were analyzed by SPECT subtraction with the volumetric MRI coregistration method using Analyze 5.0 software. <i>Results:</i> After chronic STN DBS (18 months, case 1; 6 months, case 2), both patients experienced markedly reduced seizure frequencies (86.7% reduction in patient 1, 88.6% in patient 2). In patient 1, the increased rCBF was observed in the right frontal areas (dorsolateral and inferior frontal area), which corresponded to the irritative zones as confirmed by previous EEG recording. Unexpectedly, there was definite hyperperfusion in the right superior and inferior temporal areas as well as rCBF increase in the right superior frontal area (SMA) in patient 2. <i>Conclusions:</i> We demonstrated that the cerebral perfusion increase in the irritative zones of epilepsy patients is associated with favorable seizure reduction after STN DBS in 2 cases of frontal lobe epilepsy. Although the exact mechanism remains unknown, our findings suggest that the perfusion changes after STN DBS in frontal lobe epilepsy patients are quite different from those in subjects with Parkinson’s disease. Our preliminary data suggest the clinical relevance of subtraction SPECT imaging in assessing the postprocedural outcome as well as the characteristics of SPECT perfusion patterns in other epilepsy syndromes." @default.
• W1964696307 created "2016-06-24" @default.
• W1964696307 creator A5002790890 @default.
• W1964696307 creator A5014474585 @default.
• W1964696307 creator A5033461778 @default.
• W1964696307 creator A5056890999 @default.
• W1964696307 creator A5061645251 @default.
• W1964696307 creator A5065836913 @default.
• W1964696307 creator A5068326243 @default.
• W1964696307 creator A5084491444 @default.
• W1964696307 date "2005-01-01" @default.
• W1964696307 modified "2023-10-14" @default.
• W1964696307 title "Effect of Chronic Deep Brain Stimulation of the Subthalamic Nucleus for Frontal Lobe Epilepsy: Subtraction SPECT Analysis" @default.
• W1964696307 cites W1513126258 @default.
• W1964696307 cites W1887384429 @default.
• W1964696307 cites W1966617461 @default.
• W1964696307 cites W1974809694 @default.
• W1964696307 cites W1977221546 @default.
• W1964696307 cites W1984324505 @default.
• W1964696307 cites W1989017031 @default.
• W1964696307 cites W1998055357 @default.
• W1964696307 cites W2003435725 @default.
• W1964696307 cites W2004951400 @default.
• W1964696307 cites W2026851056 @default.
• W1964696307 cites W2028681020 @default.
• W1964696307 cites W2040380321 @default.
• W1964696307 cites W2043158507 @default.
• W1964696307 cites W2053727139 @default.
• W1964696307 cites W2060116265 @default.
• W1964696307 cites W2060314229 @default.
• W1964696307 cites W2060588252 @default.
• W1964696307 cites W2060724489 @default.
• W1964696307 cites W2068047137 @default.
• W1964696307 cites W2080236966 @default.
• W1964696307 cites W2086752457 @default.
• W1964696307 cites W2097549023 @default.
• W1964696307 cites W2101562854 @default.
• W1964696307 cites W2116649573 @default.
• W1964696307 cites W2127563467 @default.
• W1964696307 cites W2134193208 @default.
• W1964696307 cites W2142625367 @default.
• W1964696307 cites W2156423414 @default.
• W1964696307 cites W2167758534 @default.
• W1964696307 cites W2171670117 @default.
• W1964696307 cites W2236528505 @default.
• W1964696307 cites W2395120772 @default.
• W1964696307 cites W29903335 @default.
• W1964696307 cites W2013995983 @default.
• W1964696307 doi "https://doi.org/10.1159/000086867" @default.
• W1964696307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16006780" @default.
• W1964696307 hasPublicationYear "2005" @default.
• W1964696307 type Work @default.
• W1964696307 sameAs 1964696307 @default.
• W1964696307 citedByCount "43" @default.
• W1964696307 countsByYear W19646963072012 @default.
• W1964696307 countsByYear W19646963072013 @default.
• W1964696307 countsByYear W19646963072014 @default.
• W1964696307 countsByYear W19646963072015 @default.
• W1964696307 countsByYear W19646963072016 @default.
• W1964696307 countsByYear W19646963072017 @default.
• W1964696307 countsByYear W19646963072018 @default.
• W1964696307 countsByYear W19646963072019 @default.
• W1964696307 countsByYear W19646963072020 @default.
• W1964696307 countsByYear W19646963072021 @default.
• W1964696307 countsByYear W19646963072022 @default.
• W1964696307 countsByYear W19646963072023 @default.
• W1964696307 crossrefType "journal-article" @default.
• W1964696307 hasAuthorship W1964696307A5002790890 @default.
• W1964696307 hasAuthorship W1964696307A5014474585 @default.
• W1964696307 hasAuthorship W1964696307A5033461778 @default.
• W1964696307 hasAuthorship W1964696307A5056890999 @default.
• W1964696307 hasAuthorship W1964696307A5061645251 @default.
• W1964696307 hasAuthorship W1964696307A5065836913 @default.
• W1964696307 hasAuthorship W1964696307A5068326243 @default.
• W1964696307 hasAuthorship W1964696307A5084491444 @default.
• W1964696307 hasConcept C126322002 @default.
• W1964696307 hasConcept C15744967 @default.
• W1964696307 hasConcept C157767197 @default.
• W1964696307 hasConcept C169760540 @default.
• W1964696307 hasConcept C2777127467 @default.
• W1964696307 hasConcept C2777319143 @default.
• W1964696307 hasConcept C2778186239 @default.
• W1964696307 hasConcept C2778542668 @default.
• W1964696307 hasConcept C2779134260 @default.
• W1964696307 hasConcept C2779734285 @default.
• W1964696307 hasConcept C2984398910 @default.
• W1964696307 hasConcept C2989005 @default.
• W1964696307 hasConcept C33923547 @default.
• W1964696307 hasConcept C42219234 @default.
• W1964696307 hasConcept C522805319 @default.
• W1964696307 hasConcept C68060419 @default.
• W1964696307 hasConcept C71924100 @default.
• W1964696307 hasConcept C94375191 @default.
• W1964696307 hasConceptScore W1964696307C126322002 @default.
• W1964696307 hasConceptScore W1964696307C15744967 @default.
• W1964696307 hasConceptScore W1964696307C157767197 @default.
• W1964696307 hasConceptScore W1964696307C169760540 @default.
• W1964696307 hasConceptScore W1964696307C2777127467 @default.

• next