FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964697262> ?p ?o ?g. }

• W1964697262 endingPage "9069" @default.
• W1964697262 startingPage "9055" @default.
• W1964697262 abstract "ABSTRACT Reactivation of latent HIV-1 infection is considered our best therapeutic means to eliminate the latent HIV-1 reservoir. Past therapeutic attempts to systemically trigger HIV-1 reactivation using single drugs were unsuccessful. We thus sought to identify drug combinations consisting of one component that would lower the HIV-1 reactivation threshold and a synergistic activator. With aclacinomycin and dactinomycin, we initially identified two FDA-approved drugs that primed latent HIV-1 infection in T cell lines and in primary T cells for reactivation and facilitated complete reactivation at the population level. This effect was correlated not with the reported primary drug effects but with the cell-differentiating capacity of the drugs. We thus tested other cell-differentiating drugs/compounds such as cytarabine and aphidicolin and found that they also primed latent HIV-1 infection for reactivation. This finding extends the therapeutic promise of N ′- N ′-hexamethylene-bisacetamide (HMBA), another cell-differentiating agent that has been reported to trigger HIV-1 reactivation, into the group of FDA-approved drugs. To this end, it is also noteworthy that suberoylanilide hydroxamic acid (SAHA), a polar compound that was initially developed as a second-generation cell-differentiating agent using HMBA as a structural template and which is now marketed as the histone deacetylase (HDAC) inhibitor vorinostat, also has been reported to trigger HIV-1 reactivation. Our findings suggest that drugs with primary or secondary cell-differentiating capacity should be revisited as HIV-1-reactivating agents as some could potentially be repositioned as candidate drugs to be included in an induction therapy to trigger HIV-1 reactivation." @default.
• W1964697262 created "2016-06-24" @default.
• W1964697262 creator A5035556913 @default.
• W1964697262 creator A5040154535 @default.
• W1964697262 creator A5040814922 @default.
• W1964697262 creator A5059159168 @default.
• W1964697262 creator A5059297961 @default.
• W1964697262 creator A5062196470 @default.
• W1964697262 creator A5063447487 @default.
• W1964697262 date "2012-09-01" @default.
• W1964697262 modified "2023-09-27" @default.
• W1964697262 title "Selected Drugs with Reported Secondary Cell-Differentiating Capacity Prime Latent HIV-1 Infection for Reactivation" @default.
• W1964697262 cites W1528329395 @default.
• W1964697262 cites W1528346173 @default.
• W1964697262 cites W1590436404 @default.
• W1964697262 cites W1598902601 @default.
• W1964697262 cites W1605366962 @default.
• W1964697262 cites W1722568879 @default.
• W1964697262 cites W1963802821 @default.
• W1964697262 cites W1964492696 @default.
• W1964697262 cites W1964849737 @default.
• W1964697262 cites W1969547164 @default.
• W1964697262 cites W1970479581 @default.
• W1964697262 cites W1970764253 @default.
• W1964697262 cites W1974766434 @default.
• W1964697262 cites W1980668957 @default.
• W1964697262 cites W1981680055 @default.
• W1964697262 cites W1982619775 @default.
• W1964697262 cites W1989600543 @default.
• W1964697262 cites W1996604523 @default.
• W1964697262 cites W1999577246 @default.
• W1964697262 cites W2001867568 @default.
• W1964697262 cites W2006364509 @default.
• W1964697262 cites W2006765654 @default.
• W1964697262 cites W2011442445 @default.
• W1964697262 cites W2013597937 @default.
• W1964697262 cites W2016939285 @default.
• W1964697262 cites W2018907710 @default.
• W1964697262 cites W2024713471 @default.
• W1964697262 cites W2027815321 @default.
• W1964697262 cites W2032025865 @default.
• W1964697262 cites W2034749827 @default.
• W1964697262 cites W2034825541 @default.
• W1964697262 cites W2035160636 @default.
• W1964697262 cites W2035813371 @default.
• W1964697262 cites W2043972038 @default.
• W1964697262 cites W2049874714 @default.
• W1964697262 cites W2051879794 @default.
• W1964697262 cites W2052173238 @default.
• W1964697262 cites W2052680578 @default.
• W1964697262 cites W2052756867 @default.
• W1964697262 cites W2063628696 @default.
• W1964697262 cites W2064743809 @default.
• W1964697262 cites W2065433806 @default.
• W1964697262 cites W2068556430 @default.
• W1964697262 cites W2070104435 @default.
• W1964697262 cites W2076805613 @default.
• W1964697262 cites W2080166804 @default.
• W1964697262 cites W2081064241 @default.
• W1964697262 cites W2084098080 @default.
• W1964697262 cites W2090669065 @default.
• W1964697262 cites W2097634003 @default.
• W1964697262 cites W2101066888 @default.
• W1964697262 cites W2102824612 @default.
• W1964697262 cites W2108422586 @default.
• W1964697262 cites W2109010689 @default.
• W1964697262 cites W2113836093 @default.
• W1964697262 cites W2117691193 @default.
• W1964697262 cites W2121443169 @default.
• W1964697262 cites W2122745942 @default.
• W1964697262 cites W2124151594 @default.
• W1964697262 cites W2125593632 @default.
• W1964697262 cites W2125638681 @default.
• W1964697262 cites W2125878780 @default.
• W1964697262 cites W2128810654 @default.
• W1964697262 cites W2132062260 @default.
• W1964697262 cites W2135540929 @default.
• W1964697262 cites W2145513589 @default.
• W1964697262 cites W2146615455 @default.
• W1964697262 cites W2148330261 @default.
• W1964697262 cites W2149767613 @default.
• W1964697262 cites W2151217565 @default.
• W1964697262 cites W2151937780 @default.
• W1964697262 cites W2166861522 @default.
• W1964697262 cites W2323874271 @default.
• W1964697262 cites W266859766 @default.
• W1964697262 cites W2885983999 @default.
• W1964697262 cites W744450912 @default.
• W1964697262 cites W90521908 @default.
• W1964697262 doi "https://doi.org/10.1128/jvi.00793-12" @default.
• W1964697262 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3416156" @default.
• W1964697262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22696646" @default.
• W1964697262 hasPublicationYear "2012" @default.
• W1964697262 type Work @default.
• W1964697262 sameAs 1964697262 @default.
• W1964697262 citedByCount "22" @default.
• W1964697262 countsByYear W19646972622013 @default.
• W1964697262 countsByYear W19646972622014 @default.

• next