FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964701241> ?p ?o ?g. }

• W1964701241 endingPage "e83270" @default.
• W1964701241 startingPage "e83270" @default.
• W1964701241 abstract "Background The clinical correlations and significance of subnormal CD4 levels in HIV-negative patients with TB are unclear. We have determined CD4 cell levels longitudinally during anti-tuberculosis treatment (ATT) in patients, with and without HIV co-infection, and their associations with clinical variables. Method Adults diagnosed with TB (maximum duration of ATT for 2 weeks, and with no history of antiretroviral therapy (ART) in HIV-positive subjects) were included consecutively in eight out-patient clinics in Ethiopia. Healthy individuals were recruited for comparison at one of the study health centers. Data on patient characteristics and physical findings were collected by trained nurses following a structured questionnaire at inclusion and on follow-up visits at 2 and 6 months. In parallel, peripheral blood CD4 cell levels were determined. The evolution of CD4 cell levels during ATT was assessed, and the association between clinical characteristics and low CD4 cell levels at baseline was investigated using regression analysis. Results In total, 1116 TB patients were included (307 HIV-infected). Among 809 HIV-negative patients, 200 (25%) had subnormal CD4 cell counts (<500 cells/mm3), with <350 cells/mm3 in 82 (10%) individuals. CD4 cell levels increased significantly during the course of ATT in both HIV+ and HIV- TB-patients, but did not reach the levels in healthy subjects (median 896 cells/mm3). Sputum smear status, signs of wasting (low mid upper arm circumference (MUAC)), and bedridden state were significantly associated with low CD4 cell counts. Conclusion A high proportion of Ethiopian TB patients have subnormal CD4 cell counts before starting treatment. Low CD4 cell levels are associated with smear positive disease and signs of wasting. The continuous increase of CD4 cell counts during the course of ATT suggest a reversible impact of active TB on CD4 cell homeostasis, which may be considered in interpretation of CD4 cell counts in HIV/TB co-infected subjects." @default.
• W1964701241 created "2016-06-24" @default.
• W1964701241 creator A5001940803 @default.
• W1964701241 creator A5004848467 @default.
• W1964701241 creator A5020449775 @default.
• W1964701241 creator A5028758479 @default.
• W1964701241 creator A5039648644 @default.
• W1964701241 creator A5048945161 @default.
• W1964701241 creator A5058849974 @default.
• W1964701241 date "2013-12-16" @default.
• W1964701241 modified "2023-10-16" @default.
• W1964701241 title "CD4 Cell Levels during Treatment for Tuberculosis (TB) in Ethiopian Adults and Clinical Markers Associated with CD4 Lymphocytopenia" @default.
• W1964701241 cites W1964919004 @default.
• W1964701241 cites W1965148277 @default.
• W1964701241 cites W1969166440 @default.
• W1964701241 cites W1975159750 @default.
• W1964701241 cites W1990501915 @default.
• W1964701241 cites W2000620558 @default.
• W1964701241 cites W2002574725 @default.
• W1964701241 cites W2007774212 @default.
• W1964701241 cites W2021085994 @default.
• W1964701241 cites W2058419095 @default.
• W1964701241 cites W2062279016 @default.
• W1964701241 cites W2075298579 @default.
• W1964701241 cites W2116169270 @default.
• W1964701241 cites W2123717316 @default.
• W1964701241 cites W2133369069 @default.
• W1964701241 cites W2133414879 @default.
• W1964701241 cites W2135833948 @default.
• W1964701241 cites W2138871014 @default.
• W1964701241 cites W2151102304 @default.
• W1964701241 cites W2160995199 @default.
• W1964701241 cites W2161784221 @default.
• W1964701241 cites W2163899436 @default.
• W1964701241 cites W2165955491 @default.
• W1964701241 doi "https://doi.org/10.1371/journal.pone.0083270" @default.
• W1964701241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3865172" @default.
• W1964701241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24358268" @default.
• W1964701241 hasPublicationYear "2013" @default.
• W1964701241 type Work @default.
• W1964701241 sameAs 1964701241 @default.
• W1964701241 citedByCount "30" @default.
• W1964701241 countsByYear W19647012412014 @default.
• W1964701241 countsByYear W19647012412015 @default.
• W1964701241 countsByYear W19647012412016 @default.
• W1964701241 countsByYear W19647012412017 @default.
• W1964701241 countsByYear W19647012412018 @default.
• W1964701241 countsByYear W19647012412019 @default.
• W1964701241 countsByYear W19647012412020 @default.
• W1964701241 countsByYear W19647012412021 @default.
• W1964701241 countsByYear W19647012412023 @default.
• W1964701241 crossrefType "journal-article" @default.
• W1964701241 hasAuthorship W1964701241A5001940803 @default.
• W1964701241 hasAuthorship W1964701241A5004848467 @default.
• W1964701241 hasAuthorship W1964701241A5020449775 @default.
• W1964701241 hasAuthorship W1964701241A5028758479 @default.
• W1964701241 hasAuthorship W1964701241A5039648644 @default.
• W1964701241 hasAuthorship W1964701241A5048945161 @default.
• W1964701241 hasAuthorship W1964701241A5058849974 @default.
• W1964701241 hasBestOaLocation W19647012411 @default.
• W1964701241 hasConcept C126322002 @default.
• W1964701241 hasConcept C142724271 @default.
• W1964701241 hasConcept C203014093 @default.
• W1964701241 hasConcept C205545832 @default.
• W1964701241 hasConcept C2776090121 @default.
• W1964701241 hasConcept C2776301714 @default.
• W1964701241 hasConcept C2777761686 @default.
• W1964701241 hasConcept C2777990475 @default.
• W1964701241 hasConcept C2779764123 @default.
• W1964701241 hasConcept C2781069245 @default.
• W1964701241 hasConcept C2993178667 @default.
• W1964701241 hasConcept C71924100 @default.
• W1964701241 hasConcept C8891405 @default.
• W1964701241 hasConcept C90924648 @default.
• W1964701241 hasConceptScore W1964701241C126322002 @default.
• W1964701241 hasConceptScore W1964701241C142724271 @default.
• W1964701241 hasConceptScore W1964701241C203014093 @default.
• W1964701241 hasConceptScore W1964701241C205545832 @default.
• W1964701241 hasConceptScore W1964701241C2776090121 @default.
• W1964701241 hasConceptScore W1964701241C2776301714 @default.
• W1964701241 hasConceptScore W1964701241C2777761686 @default.
• W1964701241 hasConceptScore W1964701241C2777990475 @default.
• W1964701241 hasConceptScore W1964701241C2779764123 @default.
• W1964701241 hasConceptScore W1964701241C2781069245 @default.
• W1964701241 hasConceptScore W1964701241C2993178667 @default.
• W1964701241 hasConceptScore W1964701241C71924100 @default.
• W1964701241 hasConceptScore W1964701241C8891405 @default.
• W1964701241 hasConceptScore W1964701241C90924648 @default.
• W1964701241 hasIssue "12" @default.
• W1964701241 hasLocation W19647012411 @default.
• W1964701241 hasLocation W19647012412 @default.
• W1964701241 hasLocation W19647012413 @default.
• W1964701241 hasLocation W19647012414 @default.
• W1964701241 hasLocation W19647012415 @default.
• W1964701241 hasLocation W19647012416 @default.
• W1964701241 hasLocation W19647012417 @default.
• W1964701241 hasOpenAccess W1964701241 @default.
• W1964701241 hasPrimaryLocation W19647012411 @default.

• next