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- W1964702364 abstract "In a previous paper (1) to clarify the physiological significance of endogenous 5-hy-droxytryptamine (5-HT) the subcellular distribution of 5-HT in rabbit brain stem has been studied and the electron microscopical structures of the fractions which contain 5-HT have been examined. 5-HT was principally found in P3-fraction which consisted largely of mitochondria and nerve-ending particles (NEPs). After density-gradient centrifuga-tion 5-HT was found to be comparatively highly concentrated in NEPs-fraction (P2B-fraction). On the other hand suspension of P2-fraction in hypo-osmotic medium and subsequent differential centrifugation resulted in high concentration of 5-HT in synaptic vesicles (sv) fraction although considerable amount of 5-HT was also found in P2D- and P2S-fraction. In general 5-HT in brain stem was not so highly concentrated in specific fraction as with the distribution of acetylcholine (ACh) (2, 3) but rather diffusibly distributed among several fractions." @default.
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- W1964702364 date "1971-01-01" @default.
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- W1964702364 title "UPTAKE AND STORAGE MECHANISM OF 5-HYDRO-XYTRYPTAMINE IN RABBIT BRAIN STEM AND EFFECT OF RESERPINE" @default.
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- W1964702364 doi "https://doi.org/10.1254/jjp.21.57" @default.
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