FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964705779> ?p ?o ?g. }

• W1964705779 endingPage "2532" @default.
• W1964705779 startingPage "2524" @default.
• W1964705779 abstract "IL-1 stimulates mesangial cells to synthesize specific proteins, including a non-pancreatic (Type II) phospholipase A2 (PLA2). We have studied the regulation of PLA2 by proinflammatory mediators, implicated in the pathogenesis of glomerulonephritis, and have assessed whether the activation of second messenger systems modulates or mimics PLA2 gene expression by cytokines. IL-1 alpha and beta, TNF alpha, and LPS, but not serum, IL-2, or PDGF, potently induce PLA2 mRNA, and enzyme expression. IL-1-stimulated mesangial cells express a 1.0 kB PLA2 mRNA transcript that is induced in a dose- and time-dependent manner. IL-1-stimulated increases in steady-state PLA2 mRNA abundance result from a moderate increase in PLA2 transcription rate that is amplified by the prolonged persistence of the transcript. Forskolin and dibutyryl cAMP potentiate IL-1-induced PLA2 mRNA and enzyme expression, but have no effect in the absence of cytokine. 12-tetradecanoyl phorbol 13-acetate, sn-1, 2-dioctanoyl glycerol or 1-oleoyl-2-acetyl-sn-glycerol fail to induce PLA2 expression or to alter the effect of IL-1 when coincubated with the cytokine. In contrast, serum deprivation for 24 h specifically enhances IL-1-stimulated PLA2. Genistein potentiates PLA2 mRNA expression in cells exposed to both IL-1 and serum. The inhibitory effect of serum on IL-1-induced PLA2 mRNA abundance is reproduced by PDGF but not dexamethasone. These data demonstrate that the signaling pathways directly engaged by IL-1 to induce PLA2 expression in mesangial cells interact with several second messenger systems in a cell-specific manner. We speculate that IL-1 induces specialized changes in mesangial cell structure and function through direct activation of a transcription factor(s), that result in induction of a specific gene set." @default.
• W1964705779 created "2016-06-24" @default.
• W1964705779 creator A5021540696 @default.
• W1964705779 creator A5071417113 @default.
• W1964705779 date "1993-11-01" @default.
• W1964705779 modified "2023-10-12" @default.
• W1964705779 title "Cell-specific regulation of type II phospholipase A2 expression in rat mesangial cells." @default.
• W1964705779 cites W1480839249 @default.
• W1964705779 cites W1482582564 @default.
• W1964705779 cites W1484515711 @default.
• W1964705779 cites W1485363868 @default.
• W1964705779 cites W1488974291 @default.
• W1964705779 cites W1500516885 @default.
• W1964705779 cites W1501182944 @default.
• W1964705779 cites W1503290529 @default.
• W1964705779 cites W1507961261 @default.
• W1964705779 cites W1513641086 @default.
• W1964705779 cites W1543377758 @default.
• W1964705779 cites W1563808745 @default.
• W1964705779 cites W1571958186 @default.
• W1964705779 cites W1577169945 @default.
• W1964705779 cites W1581760931 @default.
• W1964705779 cites W1584145849 @default.
• W1964705779 cites W1605154807 @default.
• W1964705779 cites W1605952099 @default.
• W1964705779 cites W1641540149 @default.
• W1964705779 cites W1865845936 @default.
• W1964705779 cites W1965398762 @default.
• W1964705779 cites W1968850794 @default.
• W1964705779 cites W1969979508 @default.
• W1964705779 cites W1980132152 @default.
• W1964705779 cites W1980654657 @default.
• W1964705779 cites W1987336573 @default.
• W1964705779 cites W2003996476 @default.
• W1964705779 cites W2014486946 @default.
• W1964705779 cites W2015871485 @default.
• W1964705779 cites W2021265622 @default.
• W1964705779 cites W2028242823 @default.
• W1964705779 cites W2028527050 @default.
• W1964705779 cites W2037135840 @default.
• W1964705779 cites W2038694453 @default.
• W1964705779 cites W2042260090 @default.
• W1964705779 cites W2048180296 @default.
• W1964705779 cites W2057386534 @default.
• W1964705779 cites W2084519792 @default.
• W1964705779 cites W2094530239 @default.
• W1964705779 cites W2132056777 @default.
• W1964705779 cites W2297797255 @default.
• W1964705779 cites W2411447468 @default.
• W1964705779 cites W2415678557 @default.
• W1964705779 doi "https://doi.org/10.1172/jci116861" @default.
• W1964705779 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/288438" @default.
• W1964705779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8227365" @default.
• W1964705779 hasPublicationYear "1993" @default.
• W1964705779 type Work @default.
• W1964705779 sameAs 1964705779 @default.
• W1964705779 citedByCount "31" @default.
• W1964705779 countsByYear W19647057792013 @default.
• W1964705779 countsByYear W19647057792015 @default.
• W1964705779 countsByYear W19647057792021 @default.
• W1964705779 crossrefType "journal-article" @default.
• W1964705779 hasAuthorship W1964705779A5021540696 @default.
• W1964705779 hasAuthorship W1964705779A5071417113 @default.
• W1964705779 hasBestOaLocation W19647057791 @default.
• W1964705779 hasConcept C104317684 @default.
• W1964705779 hasConcept C105580179 @default.
• W1964705779 hasConcept C126322002 @default.
• W1964705779 hasConcept C134018914 @default.
• W1964705779 hasConcept C150194340 @default.
• W1964705779 hasConcept C153911025 @default.
• W1964705779 hasConcept C164027704 @default.
• W1964705779 hasConcept C181199279 @default.
• W1964705779 hasConcept C203014093 @default.
• W1964705779 hasConcept C24998067 @default.
• W1964705779 hasConcept C2776551241 @default.
• W1964705779 hasConcept C2776914184 @default.
• W1964705779 hasConcept C2778690821 @default.
• W1964705779 hasConcept C2779131090 @default.
• W1964705779 hasConcept C2779276759 @default.
• W1964705779 hasConcept C2780091579 @default.
• W1964705779 hasConcept C54009773 @default.
• W1964705779 hasConcept C54355233 @default.
• W1964705779 hasConcept C55493867 @default.
• W1964705779 hasConcept C62478195 @default.
• W1964705779 hasConcept C71924100 @default.
• W1964705779 hasConcept C81885089 @default.
• W1964705779 hasConcept C86803240 @default.
• W1964705779 hasConcept C95444343 @default.
• W1964705779 hasConceptScore W1964705779C104317684 @default.
• W1964705779 hasConceptScore W1964705779C105580179 @default.
• W1964705779 hasConceptScore W1964705779C126322002 @default.
• W1964705779 hasConceptScore W1964705779C134018914 @default.
• W1964705779 hasConceptScore W1964705779C150194340 @default.
• W1964705779 hasConceptScore W1964705779C153911025 @default.
• W1964705779 hasConceptScore W1964705779C164027704 @default.
• W1964705779 hasConceptScore W1964705779C181199279 @default.
• W1964705779 hasConceptScore W1964705779C203014093 @default.
• W1964705779 hasConceptScore W1964705779C24998067 @default.

• next