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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964717963> ?p ?o ?g. }

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• W1964717963 abstract "A versatile synthetic route to a novel series of bis-imidazolemethanes designed to inhibit the hCMV protease has been developed and a series of potential metal binding inhibitors has been identified. In selectivity assays, the compounds were highly specific for CMV protease and showed no inhibition (IC50 > 100 microM) of other prototypical serine proteases such as trypsin, elastase, and chymotrypsin. Although the presence of free zinc ions was found to be an absolute requirement for the in vitro biological activity of this class of inhibitor, the potency of the inhibitors could not be improved beyond the micromolar level." @default.
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• W1964717963 date "2000-10-01" @default.
• W1964717963 modified "2023-10-13" @default.
• W1964717963 title "Metal mediated protease inhibition: design and synthesis of inhibitors of the human cytomegalovirus (hCMV) protease" @default.
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• W1964717963 doi "https://doi.org/10.1016/s0960-894x(00)00462-5" @default.
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