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• W1964720578 startingPage "173" @default.
• W1964720578 abstract "Background: Neutrophilic and lymphocytic vascular inflammation is common in vasculitis associated with connective tissue disease (CTD). We recently identified eight patients with CTD and eosinophilic vasculitis. Objective: The purpose of this study was to characterize a variant form of vasculitis in CTD with eosinophilic infiltration. Methods: Of 98 CTD patients with cutaneous necrotizing vasculitis, eight were found with predominantly eosinophilic vascular infiltration. Nine CTD patients with cutaneous neutrophilic vasculitis were identified for comparison. Clinical and laboratory findings were reviewed and compared. Indirect immunofluorescence for eosinophil granule major basic protein (MBP), neutrophil elastase, and mast cell tryptase was performed on lesional tissue. MBP levels and eosinophil survival enhancing activity were assayed in sera from three patients. Results: The patients with eosinophilic vasculitis had depressed serum complement levels and peripheral blood eosinophilia; MBP levels were elevated in serum and eosinophil survival was prolonged. Immunofluorescence of tissue showed marked angiocentric eosinophil MBP staining with peripheral neutrophil elastase staining; mast cell tryptase staining was notably absent. The patients with neutrophilic vasculitis were variably hypocomplementemic and did not have peripheral blood eosinophilia. Immunofluorescence showed marked angiocentric neutrophil elastase staining with scattered eosinophil MBP staining; mast cell tryptase staining showed normal mast cell numbers. Conclusion: Patients with eosinophilic vasculitis, CTD, and hypocomplementemia show vessel wall destruction in association with vessel wall deposition of cytotoxic eosinophil granule MBP, which suggests that eosinophils mediate vascular damage in this disease process. In addition, perivascular mast cells appear diminished, therby suggesting that mast cell degranulation occurs." @default.
• W1964720578 created "2016-06-24" @default.
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• W1964720578 date "1996-08-01" @default.
• W1964720578 modified "2023-10-18" @default.
• W1964720578 title "Eosinophilic vasculitis in connective tissue disease" @default.
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• W1964720578 doi "https://doi.org/10.1016/s0190-9622(96)90318-7" @default.
• W1964720578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8708015" @default.
• W1964720578 hasPublicationYear "1996" @default.
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