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- W1964725298 abstract "Cachexia, ageing and disuse and their effects on the human and animals neuromuscular system are reviewed. Disuse induces reduction of muscle fibers (mainly II) diameter with peripheral myofibrils lost; there is no core-targetoid or even reduction on myophosphorilase activity, both typical of denervation; the acetylcholine spontaneous release and trophic factors on myoneural junction are maintained; muscle fibers could change to angular shape. Ageing affects nerve and muscle by a continuous and progressive process of denervation and reinnervation; the number of motor units diminishes in sixties without any denervation electric activity; there is also reduction on the amount of ACh release on terminal neurons and mitochondrial oxidative capacity leading to compensatory type I muscle fiber number increase. Cachexia also induces reduction on muscle fibers diameter first on legs and then on arms and trunk; there is type II atrophy with occasional angular fibers, RNA/proteic synthesis reduction and normal DNA." @default.
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- W1964725298 date "1993-09-01" @default.
- W1964725298 modified "2023-10-18" @default.
- W1964725298 title "Anormalidades neuromuscular no desuso, senilidade e caquexia" @default.
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- W1964725298 doi "https://doi.org/10.1590/s0004-282x1993000300001" @default.
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