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- W1964727305 abstract "Staphylococcus aureus is one of the most successful human pathogens, colonizing 2 billion individuals worldwide and causing invasive infections even in immunocompetent hosts. S. aureus can evade multiple components of host innate immunity, including the antimicrobial radical nitric oxide (NO ⚫ ) produced by activated phagocytes. We show that S. aureus is capable of metabolically adapting to nitrosative stress by expressing an NO ⚫ -inducible l -lactate dehydrogenase ( ldh 1, SACOL0222) divergently transcribed from the NO ⚫ -detoxifying flavohemoglobin ( hmp ). l -Lactate production allows S. aureus to maintain redox homeostasis during nitrosative stress and is essential for virulence. NO ⚫ -inducible lactate dehydrogenase activity and NO ⚫ resistance distinguish S. aureus from the closely related commensal species S. epidermidis and S. saprophyticus ." @default.
- W1964727305 created "2016-06-24" @default.
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- W1964727305 date "2008-03-21" @default.
- W1964727305 modified "2023-10-03" @default.
- W1964727305 title "A Nitric Oxide–Inducible Lactate Dehydrogenase Enables <i>Staphylococcus aureus</i> to Resist Innate Immunity" @default.
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- W1964727305 doi "https://doi.org/10.1126/science.1155207" @default.
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