FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964734976> ?p ?o ?g. }

• W1964734976 endingPage "536" @default.
• W1964734976 startingPage "532" @default.
• W1964734976 abstract "Alzheimer's disease (AD) is associated with a progressive loss of locus ceruleus neurons. These noradrenergic neurons receive a major afferent projection from epinephrine neurons in epinephrine cell groups in the brainstem. The epinephrine neurons have a specific enzymatic marker, phenylethanolamine N-methyltransferase (PNMT), which allows them to be identified chemically and immunohistochemically. We have previously reported a decrease in PNMT in brains of patients with AD. We now report that the decrease in PNMT activity in projections to the locus ceruleus is not due to the loss of epinephrine neurons, although up to 33% of these neurons are atrophic. The decrease in presynaptic PNMT does, however, correlate with the loss of postsynaptic locus ceruleus neurons in brains from AD patients. The percentage of degenerating neurons in the epinephrine nuclei also correlates significantly with the amount of loss of locus ceruleus neurons in AD. In addition, there is a 55% decrease in mitogen activity, a nonspecific measure of growth or maintenance factors, in dialysed locus ceruleus extracts from the AD patients compared to those from control subjects. The mitogen activity in the locus ceruleus was significantly correlated with PNMT activity and with the density of locus ceruleus neurons in all cases examined. These findings provide evidence for the hypothesis that retrograde degeneration is a mechanism of neuronal degeneration in AD and suggest that trophic factors may play a role in this process." @default.
• W1964734976 created "2016-06-24" @default.
• W1964734976 creator A5011153326 @default.
• W1964734976 creator A5012372318 @default.
• W1964734976 creator A5013148752 @default.
• W1964734976 creator A5018303728 @default.
• W1964734976 creator A5020316181 @default.
• W1964734976 creator A5079547193 @default.
• W1964734976 creator A5079999483 @default.
• W1964734976 creator A5090578858 @default.
• W1964734976 date "1988-10-01" @default.
• W1964734976 modified "2023-09-27" @default.
• W1964734976 title "Evidence for retrograde degeneration of epinephrine neurons in Alzheimer's disease" @default.
• W1964734976 cites W1511379621 @default.
• W1964734976 cites W1548710898 @default.
• W1964734976 cites W162336345 @default.
• W1964734976 cites W170946916 @default.
• W1964734976 cites W1992192715 @default.
• W1964734976 cites W1994494533 @default.
• W1964734976 cites W1996961873 @default.
• W1964734976 cites W1998925703 @default.
• W1964734976 cites W2000598928 @default.
• W1964734976 cites W2004018976 @default.
• W1964734976 cites W2004882894 @default.
• W1964734976 cites W2005780620 @default.
• W1964734976 cites W2018222414 @default.
• W1964734976 cites W2022509291 @default.
• W1964734976 cites W2023055592 @default.
• W1964734976 cites W2023605292 @default.
• W1964734976 cites W2032212024 @default.
• W1964734976 cites W2033603470 @default.
• W1964734976 cites W2034253186 @default.
• W1964734976 cites W2034969383 @default.
• W1964734976 cites W2035339855 @default.
• W1964734976 cites W2040127402 @default.
• W1964734976 cites W2041053754 @default.
• W1964734976 cites W2050329524 @default.
• W1964734976 cites W2050665230 @default.
• W1964734976 cites W2074527580 @default.
• W1964734976 cites W2076100488 @default.
• W1964734976 cites W2076876783 @default.
• W1964734976 cites W2088479689 @default.
• W1964734976 cites W2095828172 @default.
• W1964734976 cites W2104227586 @default.
• W1964734976 doi "https://doi.org/10.1002/ana.410240409" @default.
• W1964734976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3239955" @default.
• W1964734976 hasPublicationYear "1988" @default.
• W1964734976 type Work @default.
• W1964734976 sameAs 1964734976 @default.
• W1964734976 citedByCount "49" @default.
• W1964734976 countsByYear W19647349762012 @default.
• W1964734976 countsByYear W19647349762013 @default.
• W1964734976 countsByYear W19647349762014 @default.
• W1964734976 countsByYear W19647349762016 @default.
• W1964734976 countsByYear W19647349762017 @default.
• W1964734976 countsByYear W19647349762018 @default.
• W1964734976 countsByYear W19647349762019 @default.
• W1964734976 countsByYear W19647349762020 @default.
• W1964734976 countsByYear W19647349762022 @default.
• W1964734976 countsByYear W19647349762023 @default.
• W1964734976 crossrefType "journal-article" @default.
• W1964734976 hasAuthorship W1964734976A5011153326 @default.
• W1964734976 hasAuthorship W1964734976A5012372318 @default.
• W1964734976 hasAuthorship W1964734976A5013148752 @default.
• W1964734976 hasAuthorship W1964734976A5018303728 @default.
• W1964734976 hasAuthorship W1964734976A5020316181 @default.
• W1964734976 hasAuthorship W1964734976A5079547193 @default.
• W1964734976 hasAuthorship W1964734976A5079999483 @default.
• W1964734976 hasAuthorship W1964734976A5090578858 @default.
• W1964734976 hasConcept C104317684 @default.
• W1964734976 hasConcept C126322002 @default.
• W1964734976 hasConcept C134018914 @default.
• W1964734976 hasConcept C137183658 @default.
• W1964734976 hasConcept C158453852 @default.
• W1964734976 hasConcept C159167319 @default.
• W1964734976 hasConcept C169760540 @default.
• W1964734976 hasConcept C170493617 @default.
• W1964734976 hasConcept C2775859304 @default.
• W1964734976 hasConcept C2776219046 @default.
• W1964734976 hasConcept C2776804559 @default.
• W1964734976 hasConcept C2778468602 @default.
• W1964734976 hasConcept C2779546955 @default.
• W1964734976 hasConcept C2780938664 @default.
• W1964734976 hasConcept C2909480419 @default.
• W1964734976 hasConcept C2910300410 @default.
• W1964734976 hasConcept C43310041 @default.
• W1964734976 hasConcept C513476851 @default.
• W1964734976 hasConcept C529278444 @default.
• W1964734976 hasConcept C55493867 @default.
• W1964734976 hasConcept C71924100 @default.
• W1964734976 hasConcept C84597430 @default.
• W1964734976 hasConcept C86803240 @default.
• W1964734976 hasConceptScore W1964734976C104317684 @default.
• W1964734976 hasConceptScore W1964734976C126322002 @default.
• W1964734976 hasConceptScore W1964734976C134018914 @default.
• W1964734976 hasConceptScore W1964734976C137183658 @default.
• W1964734976 hasConceptScore W1964734976C158453852 @default.
• W1964734976 hasConceptScore W1964734976C159167319 @default.

• next