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- W1964740147 abstract "Serum IGF levels were assayed, after acid extraction, in 26 girls and 32 boys (aged 1 - 22) whose height for their age exceed 3 SD, by a radioligand assay using human ICF (gift from Dr Zapf, Zürich) and a specific binding protein produced by rat liver in culture. Results are expressed in relation to a pool of normal adult serum arbitrarily assigned a value of 1 U/ml. 1) For the 15 children aged 1-10, the mean IGF level was 0.83 ± 0.09 (SEM) U/ml which is significantly higher than that for normal children (0.59 ± 0.05, n = 29) (p <0.01). 2) In the 21 10-15 year-old, IGF levels (1.35 ± 0.09) were higher than controls (1.05 ± 0.08, n = 18) (p< 0.01). 7 girls and 1 boy had levels (1.52 - 2.46) comparable to those of untreated acromegalics. GH levels 60 min after glucose load (30 g/m2) were < 5 ng/ml in 11 subjects studied. 3) In the 22 patients over 15, IGF levels (1.09 ± 0.07) were similar to those of normal adults (1.06 ± 0.03 U/ml). 4) In 10 girls under ethinyloestradiol (200-300 μg/day) for a prognosis of a final height exceeding 180 cm, parallel with the decrease in growth, there was a slow but progressive drop in IGF levels (means : 1.49 U/ml after 3 months, 1.08 after 1 year). The abnormally high IGF levels seen with idiopathic tall stature and the drop accompanying oestrogen therapy suggest a direct relation between IGF production and growth rate. The return to normal levels once ossification is complete suggests a regulatory disorder during the growth period." @default.
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- W1964740147 date "1981-12-01" @default.
- W1964740147 modified "2023-10-18" @default.
- W1964740147 title "IGF (insulin-like growth factor) levels in cases of idiopathic tall stature" @default.
- W1964740147 doi "https://doi.org/10.1203/00006450-198112000-00057" @default.
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