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- W1964743024 abstract "Activated antigen-presenting cells and central nervous system microglia produce IL-1β, TNF-α, IL-6, and PGE1. These monokines participate in the lymphocyte activation, demyelination, and intrathecal immunoglobulin synthesis seen in multiple sclerosis (MS). Exacerbations of MS are ameliorated by IFN-β, but provoked by IFN-γ, possibly through an effect on monocytes (Mo). We studied the effects of IFNs and PG on monokine secretion under stringent low-endotoxin conditions. Spontaneous and IFN-γ-induced IL-1β secretion was greater in MS than in NL Mo. IFN-β did not inhibit IFN-γ-induced secretion of monokines, which contrasts with IFN-β's inhibitory effect on IFN-γ-induced MHC class II expression. PGEt, a cAMP agonist, caused a 30-fold induction of IL-6 secretion. Indomethacin directly inhibited this induction. Low-close IFN-β, through effects on T cells, and cAMP agonists, through effects in T cells and Mo, may ameliorate inflammatory diseases characterized by excessive monokine secretion." @default.
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- W1964743024 date "1994-09-01" @default.
- W1964743024 modified "2023-10-13" @default.
- W1964743024 title "IFN-γ, IFN-β, and PGE Affect Monokine Secretion: Relevance to Monocyte Activation in Multiple Sclerosis" @default.
- W1964743024 doi "https://doi.org/10.1006/cimm.1994.1239" @default.
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