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• W1964749557 abstract "<i>N</i>-Nitrosation in oxygenated nitric oxide (NO·) solutions was previously shown to be significantly inhibited by phosphate and chloride presumably by anion scavenging of the nitrosating agent nitrous anhydride, N₂O₃ (Lewis, R. S., Tannenbaum, S. R., and Deen, W. M. (1995) <i>J. Am. Chem. Soc.</i> 117, 3933-3939). Here, bicarbonate is shown to exhibit this same inhibitory effect. Rate constants for reaction of morpholine, phosphate, and bicarbonate with N₂O₃ relative to N₂O₃ hydrolysis at pH 8.9 were determined to be (3.7 ± 0.2) × 10⁴M⁻¹, (4.0 ± 0.9) × 10²M⁻¹, and (9.3 ± 1.5) × 10²M⁻¹, respectively. The morpholine and phosphate rate constants at pH 8.9 are similar to those reported at pH 7.4 assuring that these results are relevant to physiological conditions. The rate constant for this previously unrecognized reaction of bicarbonate with N₂O₃ suggests the strong scavenging ability of bicarbonate; accordingly, bicarbonate may contribute to reducing deleterious effects of N₂O₃. This is biologically important due to substantial bicarbonate concentrations <i>in vivo</i>, approximately 30 mM. Bicarbonate was previously shown to alter peroxynitrite reactivity; however, carbon dioxide is the probable reactive species. Bicarbonate is therefore potentially important in determining the fate of two reactive species generated from nitric oxide, N₂O₃ and ONOO⁻, and may thus act as a regulator of NO·-induced toxicity." @default.
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• W1964749557 date "1996-10-01" @default.
• W1964749557 modified "2023-10-12" @default.
• W1964749557 title "Bicarbonate Inhibits N-Nitrosation in Oxygenated Nitric Oxide Solutions" @default.
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• W1964749557 doi "https://doi.org/10.1074/jbc.271.42.25859" @default.
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