FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964763257> ?p ?o ?g. }

• W1964763257 endingPage "5089" @default.
• W1964763257 startingPage "5079" @default.
• W1964763257 abstract "A fundamental yet unexplored question in stem cell biology is how the fate of tissue stem cells is initially determined during development. In Drosophila, germline stem cells (GSCs) descend from a subset of primordial germ cells (PGCs) at the onset of oogenesis. GSC determination may occur at the onset of oogenesis when a subset of PGCs is induced to become GSCs by contacting niche cells. Alternatively, the GSC fate could be predetermined for a subset of PGCs before oogenesis, due to either their interaction with specific somatic cells in the embryonic/larval gonads, or their inherently heterogeneous potential in becoming GSCs, or both. Here, we show that anterior somatic cells in the embryonic gonad already differ from posterior somatic cells and are likely to be the precursors of niche cells in the adult ovary. Furthermore, only pole cells in the anterior half of the embryonic gonad give rise to the PGCs that frequently acquire contact with nascent niche cells in the late larval ovary. Eventually, only these contacting PGCs become GSCs, whereas non-contacting PGCs directly differentiate into cystoblasts. The strong preference of these `anterior PGCs'towards contacting niche cells does not require DE-cadherin-mediated adhesion and is not correlated with either orientation or rate of their divisions. These data suggest that the GSC fate is predetermined before oogenesis. The predetermination probably involves soma/pole-cell interaction in the anterior half of the embryonic gonad, followed by an active homing mechanism during PGC proliferation to maintain the contact between the `anterior PGCs' and anterior somatic cells." @default.
• W1964763257 created "2016-06-24" @default.
• W1964763257 creator A5007131600 @default.
• W1964763257 creator A5016698988 @default.
• W1964763257 date "2004-10-15" @default.
• W1964763257 modified "2023-10-17" @default.
• W1964763257 title "Germline stem cells in the<i>Drosophila</i>ovary descend from pole cells in the anterior region of the embryonic gonad" @default.
• W1964763257 cites W1507545655 @default.
• W1964763257 cites W1555563809 @default.
• W1964763257 cites W1600103888 @default.
• W1964763257 cites W1793536857 @default.
• W1964763257 cites W1833330721 @default.
• W1964763257 cites W1845807280 @default.
• W1964763257 cites W1889389895 @default.
• W1964763257 cites W1904289401 @default.
• W1964763257 cites W1938204331 @default.
• W1964763257 cites W1947138928 @default.
• W1964763257 cites W1972812055 @default.
• W1964763257 cites W1983952522 @default.
• W1964763257 cites W2012812443 @default.
• W1964763257 cites W2027384096 @default.
• W1964763257 cites W2029086784 @default.
• W1964763257 cites W2032165553 @default.
• W1964763257 cites W2037048003 @default.
• W1964763257 cites W2043495620 @default.
• W1964763257 cites W2049255037 @default.
• W1964763257 cites W2061848524 @default.
• W1964763257 cites W2063595681 @default.
• W1964763257 cites W2064236697 @default.
• W1964763257 cites W2064695569 @default.
• W1964763257 cites W2065258374 @default.
• W1964763257 cites W2066818389 @default.
• W1964763257 cites W2069498156 @default.
• W1964763257 cites W2074328073 @default.
• W1964763257 cites W2085499501 @default.
• W1964763257 cites W2100050856 @default.
• W1964763257 cites W2101027598 @default.
• W1964763257 cites W2111069555 @default.
• W1964763257 cites W2121350246 @default.
• W1964763257 cites W2135958480 @default.
• W1964763257 cites W2152438025 @default.
• W1964763257 cites W2165780130 @default.
• W1964763257 cites W2167644662 @default.
• W1964763257 cites W2172088581 @default.
• W1964763257 cites W2183954446 @default.
• W1964763257 cites W3163992754 @default.
• W1964763257 doi "https://doi.org/10.1242/dev.01391" @default.
• W1964763257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15459101" @default.
• W1964763257 hasPublicationYear "2004" @default.
• W1964763257 type Work @default.
• W1964763257 sameAs 1964763257 @default.
• W1964763257 citedByCount "53" @default.
• W1964763257 countsByYear W19647632572012 @default.
• W1964763257 countsByYear W19647632572013 @default.
• W1964763257 countsByYear W19647632572014 @default.
• W1964763257 countsByYear W19647632572015 @default.
• W1964763257 countsByYear W19647632572018 @default.
• W1964763257 countsByYear W19647632572019 @default.
• W1964763257 countsByYear W19647632572020 @default.
• W1964763257 countsByYear W19647632572021 @default.
• W1964763257 countsByYear W19647632572023 @default.
• W1964763257 crossrefType "journal-article" @default.
• W1964763257 hasAuthorship W1964763257A5007131600 @default.
• W1964763257 hasAuthorship W1964763257A5016698988 @default.
• W1964763257 hasConcept C104317684 @default.
• W1964763257 hasConcept C105702510 @default.
• W1964763257 hasConcept C109825262 @default.
• W1964763257 hasConcept C134305767 @default.
• W1964763257 hasConcept C145103041 @default.
• W1964763257 hasConcept C163949779 @default.
• W1964763257 hasConcept C196843134 @default.
• W1964763257 hasConcept C2776690073 @default.
• W1964763257 hasConcept C2781471917 @default.
• W1964763257 hasConcept C28328180 @default.
• W1964763257 hasConcept C54355233 @default.
• W1964763257 hasConcept C86803240 @default.
• W1964763257 hasConcept C95444343 @default.
• W1964763257 hasConceptScore W1964763257C104317684 @default.
• W1964763257 hasConceptScore W1964763257C105702510 @default.
• W1964763257 hasConceptScore W1964763257C109825262 @default.
• W1964763257 hasConceptScore W1964763257C134305767 @default.
• W1964763257 hasConceptScore W1964763257C145103041 @default.
• W1964763257 hasConceptScore W1964763257C163949779 @default.
• W1964763257 hasConceptScore W1964763257C196843134 @default.
• W1964763257 hasConceptScore W1964763257C2776690073 @default.
• W1964763257 hasConceptScore W1964763257C2781471917 @default.
• W1964763257 hasConceptScore W1964763257C28328180 @default.
• W1964763257 hasConceptScore W1964763257C54355233 @default.
• W1964763257 hasConceptScore W1964763257C86803240 @default.
• W1964763257 hasConceptScore W1964763257C95444343 @default.
• W1964763257 hasIssue "20" @default.
• W1964763257 hasLocation W19647632571 @default.
• W1964763257 hasLocation W19647632572 @default.
• W1964763257 hasOpenAccess W1964763257 @default.
• W1964763257 hasPrimaryLocation W19647632571 @default.
• W1964763257 hasRelatedWork W1932794209 @default.
• W1964763257 hasRelatedWork W2070532728 @default.
• W1964763257 hasRelatedWork W2086992211 @default.

• next