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- W1964768317 abstract "Voltage-dependent K+ (Kv) channels are tightly regulated during the immune system response. Leukocytes have a limited repertoire of Kv channels, whose physiological role is under intense investigation. A functional Kv channel is an oligomeric complex composed of pore-forming and ancillary subunits. The KCNE gene family is a novel group of modulatory Kv channel elements in leukocytes. Here, we characterized the gene expression of KCNEs (1–5) in leukocytes and investigated their regulation during leukocyte proliferation and mode of activation. Murine bone-marrow-derived macrophages, human Jurkat T-lymphocytes and human Raji B-cells were analyzed. KCNEs (1–5) are expressed in all leukocytes lineages. Most KCNE mRNAs show cell cycle-dependent regulation and are differentially regulated under specific insults. Our results further suggest a new and yet undefined physiological role for KCNE subunits in the immune system. Putative associations of these ancillary proteins with Kv channels would yield a wide variet..." @default.
- W1964768317 created "2016-06-24" @default.
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- W1964768317 date "2013-03-17" @default.
- W1964768317 modified "2023-10-16" @default.
- W1964768317 title "KCNE gene expression is dependent on the proliferation and mode of activation of leukocytes" @default.
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- W1964768317 doi "https://doi.org/10.4161/chan.23258" @default.
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