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- W1964775841 abstract "The metabolism of 19-norandrostenedione and [3H]19-nortestosterone was examined in porcine Leydig cell preparations in the absence, or presence, of a 4-aza-steroid inhibitor of 5α-reductase. Evidence for a major production of 5α-estrane-3β, 17β-diol and 3β-hydroxy-5α-estran-17-one, as sulfo-conjugated steroids, was obtained by HPLC and gas-chromatography/mass spectrometry. The 4-aza-steroid clearly reduced the formation of both of the above 5α-reduced products from the 19-norandrogens. From the HPLC profiles of the radioactive metabolites, it was also concluded that estrogen secretion was increased significantly by exposure of the cells to the 5α-reductase inhibitor." @default.
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- W1964775841 date "1992-03-01" @default.
- W1964775841 modified "2023-09-24" @default.
- W1964775841 title "Effect of a 5α-reductase inhibitor on the metabolism of 19-norandrogens by porcine leydig cells" @default.
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- W1964775841 doi "https://doi.org/10.1016/s0006-291x(05)80325-0" @default.
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