Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964778879> ?p ?o ?g. }
- W1964778879 endingPage "18891" @default.
- W1964778879 startingPage "18884" @default.
- W1964778879 abstract "In vitro protein-folding studies using chemical denaturants such as urea are indispensible in elucidating the forces and mechanisms determining the stability, structure, and dynamics of water-soluble proteins. By contrast, α-helical membrane-associated proteins largely evade such approaches because they are resilient to extensive unfolding. We have used optical and NMR spectroscopy to provide an atomistic-level dissection of the effects of urea on the structure and dynamics of the α-helical membrane-associated protein Mistic as well as its interactions with detergent and solvent molecules. In the presence of the zwitterionic detergent lauryl dimethylamine oxide, increasing concentrations of urea result in a complex sequence of conformational changes that go beyond simple two-state unfolding. Exploiting this finding, we report the first high-resolution structural models of the urea denaturation process of an α-helical membrane-associated protein and its completely unfolded state, which contains almost no regular secondary structure but nevertheless retains a topology close to that of the folded state." @default.
- W1964778879 created "2016-06-24" @default.
- W1964778879 creator A5008249625 @default.
- W1964778879 creator A5017414147 @default.
- W1964778879 creator A5034988490 @default.
- W1964778879 creator A5038637632 @default.
- W1964778879 creator A5040084490 @default.
- W1964778879 creator A5040815003 @default.
- W1964778879 creator A5070615709 @default.
- W1964778879 creator A5073120490 @default.
- W1964778879 creator A5083707774 @default.
- W1964778879 creator A5087161710 @default.
- W1964778879 creator A5089662436 @default.
- W1964778879 date "2013-12-04" @default.
- W1964778879 modified "2023-10-05" @default.
- W1964778879 title "The Mechanism of Denaturation and the Unfolded State of the α-Helical Membrane-Associated Protein Mistic" @default.
- W1964778879 cites W1516339579 @default.
- W1964778879 cites W1534365818 @default.
- W1964778879 cites W1963525648 @default.
- W1964778879 cites W1974129871 @default.
- W1964778879 cites W1979430872 @default.
- W1964778879 cites W1980176289 @default.
- W1964778879 cites W1980676977 @default.
- W1964778879 cites W1982581985 @default.
- W1964778879 cites W1984900307 @default.
- W1964778879 cites W1985716931 @default.
- W1964778879 cites W1994446262 @default.
- W1964778879 cites W1996222219 @default.
- W1964778879 cites W1996518756 @default.
- W1964778879 cites W2004079991 @default.
- W1964778879 cites W2004688141 @default.
- W1964778879 cites W2007871993 @default.
- W1964778879 cites W2009973554 @default.
- W1964778879 cites W2010499374 @default.
- W1964778879 cites W2011630467 @default.
- W1964778879 cites W2017292800 @default.
- W1964778879 cites W2017371394 @default.
- W1964778879 cites W2017505620 @default.
- W1964778879 cites W2019215286 @default.
- W1964778879 cites W2019955130 @default.
- W1964778879 cites W2020570580 @default.
- W1964778879 cites W2023561215 @default.
- W1964778879 cites W2028053333 @default.
- W1964778879 cites W2028556267 @default.
- W1964778879 cites W2043020321 @default.
- W1964778879 cites W2044718347 @default.
- W1964778879 cites W2045828736 @default.
- W1964778879 cites W2050880321 @default.
- W1964778879 cites W2054137332 @default.
- W1964778879 cites W2055307767 @default.
- W1964778879 cites W2056903144 @default.
- W1964778879 cites W2058594103 @default.
- W1964778879 cites W2060463651 @default.
- W1964778879 cites W2063044149 @default.
- W1964778879 cites W2067798279 @default.
- W1964778879 cites W2071396753 @default.
- W1964778879 cites W2080737411 @default.
- W1964778879 cites W2083516494 @default.
- W1964778879 cites W2083939457 @default.
- W1964778879 cites W2103275034 @default.
- W1964778879 cites W2103751982 @default.
- W1964778879 cites W2125823338 @default.
- W1964778879 cites W2127395373 @default.
- W1964778879 cites W2132057460 @default.
- W1964778879 cites W2133349905 @default.
- W1964778879 cites W2134609303 @default.
- W1964778879 cites W2135060180 @default.
- W1964778879 cites W2156771958 @default.
- W1964778879 cites W2160569176 @default.
- W1964778879 cites W2170823043 @default.
- W1964778879 cites W278916191 @default.
- W1964778879 cites W4229743141 @default.
- W1964778879 doi "https://doi.org/10.1021/ja408644f" @default.
- W1964778879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24261476" @default.
- W1964778879 hasPublicationYear "2013" @default.
- W1964778879 type Work @default.
- W1964778879 sameAs 1964778879 @default.
- W1964778879 citedByCount "17" @default.
- W1964778879 countsByYear W19647788792014 @default.
- W1964778879 countsByYear W19647788792015 @default.
- W1964778879 countsByYear W19647788792016 @default.
- W1964778879 countsByYear W19647788792017 @default.
- W1964778879 countsByYear W19647788792018 @default.
- W1964778879 countsByYear W19647788792019 @default.
- W1964778879 countsByYear W19647788792021 @default.
- W1964778879 crossrefType "journal-article" @default.
- W1964778879 hasAuthorship W1964778879A5008249625 @default.
- W1964778879 hasAuthorship W1964778879A5017414147 @default.
- W1964778879 hasAuthorship W1964778879A5034988490 @default.
- W1964778879 hasAuthorship W1964778879A5038637632 @default.
- W1964778879 hasAuthorship W1964778879A5040084490 @default.
- W1964778879 hasAuthorship W1964778879A5040815003 @default.
- W1964778879 hasAuthorship W1964778879A5070615709 @default.
- W1964778879 hasAuthorship W1964778879A5073120490 @default.
- W1964778879 hasAuthorship W1964778879A5083707774 @default.
- W1964778879 hasAuthorship W1964778879A5087161710 @default.
- W1964778879 hasAuthorship W1964778879A5089662436 @default.
- W1964778879 hasConcept C119599485 @default.