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• W1964793052 abstract "BACKGROUND: Platelets (PLTs) contain purinergic receptors for ATP (P2X 1 ) and ADP (P2Y 1 and P2Y 12 ) that rapidly desensitize upon stimulation with these nucleotides. In vivo, this is antagonized by ectonucleotidases on the surface of endothelial cells and white blood cells (WBCs). The receptor desensitization of ATP‐ and ADP‐induced responses of PLTs stored in plasma without WBCs was investigated. STUDY DESIGN AND METHODS: ATP‐ and ADP‐induced PLT shape change (shear‐induced) aggregation and Ca 2+ signaling were measured in the presence or absence of plasma. Degradation of nucleotides in plasma was quantified by high‐performance liquid chromatography. RESULTS: Washed PLTs became refractory for ATP and ADP in shape change, aggregation, and Ca 2+ responses during a 90‐minute incubation at 37°C. The PLT responses mediated by P2X 1 , P2Y 1 , and P2Y 12 receptors gradually reduced or disappeared. When plasma was present, however, the PLTs persistently showed high responses to ATP and ADP. Heat treatment of plasma abolished this effect. Also under conditions of flow and high shear, PLTs in plasma kept high P2X 1 activity, mediating aggregate formation. In isolated plasma, not containing WBCs, nucleotides were degraded in the order of ADP/UDP > ATP/UTP. Degradation of ATP was partly inhibited by blocking the ecto‐NTPDase CD39, whereas degradation of both ATP and ADP was inhibited by blocking ectopyrophosphatase/phosphodiesterase activity. Part of the nucleotide‐degrading activities appeared to be membrane‐bound. CONCLUSION: Ectonucleotidases in plasma preserve the functionality of P2X 1 and P2Y receptors. Upon PLT storage, these plasma activities are essential to ensure adequate (shear‐dependent) formation of aggregates and thrombi." @default.
• W1964793052 created "2016-06-24" @default.
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• W1964793052 date "2006-05-24" @default.
• W1964793052 modified "2023-10-18" @default.
• W1964793052 title "Plasma ectonucleotidases prevent desensitization of purinergic receptors in stored platelets: importance for platelet activity during thrombus formation" @default.
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• W1964793052 doi "https://doi.org/10.1111/j.1537-2995.2006.00837.x" @default.
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